Catalytic asymmetric synthesis of alpha- and beta-amino phosphonic acid derivatives.
Catalytic asymmetric synthesis of alpha- and beta-amino phosphonic acid derivatives.
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作者：
Jun‐An Ma
催化不对称反应是合成对映体富集化合物最有效、最经济的方法之一。作为相应的α-和β-氨基酸的类似物，光学活性的α-和β-氨基膦酸衍生物已广泛用于药物化学和制药科学中。利用催化量的手性物质，不对称合成对映体富集的α-和β-氨基膦酸酯已成为一个越来越感兴趣的课题。本教程回顾包含了迄今为止开发的催化不对称合成方法的汇编，并强调了它们用于获得这些目标化合物的实用性。
Catalytic asymmetric reactions provide one of the most powerful and economical synthetic approaches to a variety of enantiomerically enriched compounds. As being analogues of the corresponding alpha- and beta-amino acids, optically active alpha- and beta-amino phosphonic acid derivatives have found widespread use in medicinal chemistry and the pharmaceutical sciences. Using catalytic amounts of chiral materials, asymmetric synthesis of enantiomerically enriched alpha- and beta-amino phosphonates has been a subject of growing interest. This tutorial review contains a compilation of the catalytic asymmetric synthetic methods developed to date and highlights their utility for obtaining these target compounds.