Graphene oxide used as a carrier for adriamycin can reverse drug resistance in breast cancer cells
Graphene oxide used as a carrier for adriamycin can reverse drug resistance in breast cancer cells
复制标题
氧化石墨烯用作阿霉素载体可逆转乳腺癌细胞的耐药性
DOI：
10.1088/0957-4484/23/35/355101
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发表时间：
2012-09-07
期刊：
影响因子：
3.5
通讯作者：
Zhang, Ning
中科院分区：
文献类型：
--
作者：
Wu, Jing;Wang, Yin-song;Zhang, Ning
This study evaluates the reversal effects of graphene oxide (GO) used as a carrier for adriamycin (ADR) in cancer drug resistance, and provides a preliminary investigation into the reversal mechanism. ADR was loaded onto the GO surface (ADR-GO) by physical mixing and drug loading content was found to be high, up to 93.6%. In vitro releases of ADR from ADR-GO were studied using a dialysis method, and they exhibited a significant pH-sensitive property. Cell experiments showed that GO significantly enhanced the accumulation of ADR in MCF-7/ADR cells (an ADR resistant breast cancer cell line) and exhibited much higher cytotoxicity than free ADR, suggesting that ADR-GO could effectively reverse ADR resistance of MCF-7/ADR, with the reversal index reaching 8.35. Microscopy studies found that GO could effectively carry drug molecules into cells in both endocytosis-dependent and independent manners. In conclusion, use of GO as a carrier for chemotherapeutic agents is favorable for the treatment of drug resistant cancers.
