Skeletal muscle mitochondrial uncoupling, adaptive thermogenesis and energy expenditure
Skeletal muscle mitochondrial uncoupling, adaptive thermogenesis and energy expenditure
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DOI：
10.1097/mco.0b013e3283455d7a
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发表时间：
2011-05-01
影响因子：
3.1
通讯作者：
Schrauwen, Patrick
中科院分区：
文献类型：
--
作者：
van den Berg, Sjoerd A. A.;Lichtenbelt, Wouter van Marken;Schrauwen, Patrick
综述目的尽管肥胖症治疗策略旨在减少能量摄入，但肥胖症的患病率仍在增加。除此之外，旨在增加能量消耗的锻炼方案效率很低，产生的结果好坏参半。因此，目前正在研究通过非运动方式增加能量消耗的策略。一种新的策略是调节适应性产热。最近的发现，适应性产热可以通过改变饮食组成，激素模拟物治疗以及冷暴露来调节。在人类中，除了棕色脂肪组织的假定作用外，大部分适应性产热反应是通过线粒体解偶联过程由骨骼肌质量决定的。在这里，我们描述了参与线粒体解偶联的分子过程，体外和体内测量线粒体解偶联的最新技术，在啮齿动物和人类中产生的数据暗示，通过增加骨骼肌线粒体解偶联来增加适应性产热确实提高了总能量消耗，因此可能为治疗糖尿病提供有希望的靶点。肥胖
Purpose of reviewThe prevalence of obesity is still increasing, despite obesity treatment strategies that aim at reducing energy intake. In addition to this, exercise programmes designed to increase energy expenditure have only a low efficiency and have generated mixed results. Therefore, strategies based on increasing energy expenditure via nonexercise means are currently under investigation. One novel strategy is the modulation of adaptive thermogenesis.Recent findingsAmong others, adaptive thermogenesis can be modulated by changing dietary composition, treatment with hormone mimetics as well as by cold exposure. In humans, a large part of the adaptive thermogenic response is, in addition to a putative role of brown adipose tissue, determined by the skeletal muscle mass via the process of mitochondrial uncoupling. Here, we describe the molecular processes involved in mitochondrial uncoupling, state-of-the-art techniques to measure mitochondrial uncoupling in vitro and in vivo, as well as the current strategies to mitochondrial uncoupling.SummaryData generated in rodents and humans implicate that increasing adaptive thermogenesis by increasing skeletal muscle mitochondrial uncoupling indeed elevates total energy expenditure and thus may provide a promising target for the treatment of obesity.