The Quest to Eradicate HPV-Related Oropharyngeal Carcinoma: An Opportunity Not to Miss
The Quest to Eradicate HPV-Related Oropharyngeal Carcinoma: An Opportunity Not to Miss
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DOI：
10.1093/jnci/djac098
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发表时间：
2022-05-14
影响因子：
10.3
通讯作者：
Saba, Nabil F.
中科院分区：
文献类型：
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作者：
Lalonde, Chloe S.;Teng, Yong;Saba, Nabil F.
口咽鳞状细胞癌（OPSCC）占所有头颈部癌症的一半以上。自20世纪70年代以来，由于人乳头瘤病毒（HPV）相关的鳞状细胞癌的急剧增加，OPSCC已经从环境引发的疾病转变为病毒介导的疾病。虽然有一种非常有效的预防性疫苗，但目前的实施情况远远低于国家目标，预计到2045年，OPSCC发病率将进一步增加。然而，我们相信，只要现在采取迅速行动，我们不仅可以推翻这些预测，而且可以在未来20年内有效地根除hpv相关的OPSCC。我们在此概述了消除这种疾病的必要因素：提高初级疫苗的吸收率，一次性普遍接种疫苗的努力，以及有可能治愈现有疾病的新疗法的实施。
Oropharyngeal squamous cell carcinoma (OPSCC) accounts for more than half of all head and neck cancers. Since the 1970s, OPSCC has shifted from an environmentally triggered to virally mediated disease due to a sharp rise in human papillomavirus (HPV)-related squamous cell carcinoma. Although a highly effective prophylactic vaccine is available, its current implementation is far below national targets, and OPSCC incidence is predicted to further increase by 2045. However, we believe that with prompt action now, we can not only defy these predictions but also effectively eradicate HPV-related OPSCC in these next 20 years. We herein provide an overview of the necessary elements to eliminate this disease: improved primary vaccine uptake, a 1-time universal vaccination effort, and implementation of novel therapeutics that have potential to cure existing disease.