Prefrontal Neurons Represent Winning and Losing during Competitive Video Shooting Games between Monkeys
Prefrontal Neurons Represent Winning and Losing during Competitive Video Shooting Games between Monkeys
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DOI：
10.1523/jneurosci.6479-11.2012
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发表时间：
2012-05-30
影响因子：
5.3
通讯作者：
Watanabe, Masataka
中科院分区：
文献类型：
--
作者：
Hosokawa, Takayuki;Watanabe, Masataka
人类和动物必须努力支持他们的生存和生殖需求。由于自然环境中的资源是有限的，竞争是不可避免的，而竞争成功至关重要。然而，竞争行为的神经元机制研究甚少。我们研究了外侧前额叶皮层（LPFC）的神经元是否表现出与竞争性游戏相关的反应敏感性。在这项研究中，猴子们玩了一个视频射击游戏，要么与另一只猴子或电脑竞争，要么独自玩没有对手的游戏。猴子在竞争性游戏中比在非竞争性游戏中表现得更快、更准确，这表明它们在竞争性游戏中比在非竞争性游戏中更有动力。LPFC神经元在竞争性和非竞争性游戏中表现出不同的活动，显示出与输赢相关的活动。此外，前额叶神经元的活动取决于是猴子之间的竞争还是猴子与计算机之间的竞争。这些结果表明，LPFC神经元可能在监测竞争结果和使动物能够调整其行为以增加其在社交互动环境中获得奖励的机会方面发挥重要作用。
Humans and animals must work to support their survival and reproductive needs. Because resources are limited in the natural environment, competition is inevitable, and competing successfully is vitally important. However, the neuronal mechanisms of competitive behavior are poorly studied. We examined whether neurons in the lateral prefrontal cortex (LPFC) showed response sensitivity related to a competitive game. In this study, monkeys played a video shooting game, either competing with another monkey or the computer, or playing alone without a rival. Monkeys performed more quickly and more accurately in the competitive than in the noncompetitive games, indicating that they were more motivated in the competitive than in the noncompetitive games. LPFC neurons showed differential activity between the competitive and noncompetitive games showing winning- and losing-related activity. Furthermore, activities of prefrontal neurons differed depending on whether the competition was between monkeys or between the monkey and the computer. These results indicate that LPFC neurons may play an important role in monitoring the outcome of competition and enabling animals to adapt their behavior to increase their chances of obtaining a reward in a socially interactive environment.