Filling and arterial pressures as determinants of RV stroke volume in the sheep fetus.
Filling and arterial pressures as determinants of RV stroke volume in the sheep fetus.
复制标题
充盈度和动脉压是羊胎儿右心室每搏输出量的决定因素。
DOI：
--
复制
发表时间：
1983
影响因子：
--
通讯作者：
M. Morton
中科院分区：
文献类型：
--
作者：
K. Thornburg;M. Morton
在9只胎羊（妊娠125-130天）体内植入肺动脉电磁流量传感器和血管导管，研究右心室（RV）功能。对照动脉CO2和O2张力、pH值和红细胞压积值分别为46.1 +/- 1.6（SD）Torr、20.6 +/- 1.8 Torr、7.39 +/- 0.02和31 +/-5.3%。右心室输出量的控制值（247 ± 75 ml X min-1 X kg-1），每搏输出量（SV，1.5 +/- 0.4 ml X kg-1），右心房压（3.7 +/- 1.2 mmHg），心率（166 +/- 18次心跳X min-1）和动脉压（AP，43 +/- 4 mmHg）未因阿托品和普萘洛尔给药而发生变化。在低、正常和高动脉压下，抽取和输注胎血，同时输注或不同时输注硝普钠或苯肾上腺素产生RV功能曲线。所有功能曲线都有陡峭的上升支和平台。连接对照曲线分支的断点为右心房压力3.4 +/- 1.2 mmHg和SV 1.5 +/- 0.4 ml X kg-1。AP增加使断点向下移动。右心房压力大于断点时，SV对AP从15到95 mmHg的线性回归为SV = -0.016 ml X kg-1 mmHg-1 X AP + 2.25 ml X kg-1。
Right ventricular (RV) function was investigated in nine fetal lambs (125-130 days gestation) that were instrumented with pulmonary artery electromagnetic flow sensors and vascular catheters. Control arterial CO2 and O2 tension, pH, and hematocrit values were 46.1 +/- 1.6 (SD) Torr, 20.6 +/- 1.8 Torr, 7.39 +/- 0.02, and 31 +/- 5.3%, respectively. Control values for right ventricular output (247 +/- 75 ml X min-1 X kg-1), stroke volume (SV, 1.5 +/- 0.4 ml X kg-1), right atrial pressure (3.7 +/- 1.2 mmHg), heart rate (166 +/- 18 beats X min-1), and arterial pressure (AP, 43 +/- 4 mmHg) were unchanged by administration of atropine and propranolol. Withdrawal and infusion of fetal blood with or without concomitant infusion of nitroprusside or phenylephrine produced RV function curves at low, normal, and high arterial pressures. All function curves had a steep ascending limb and a plateau. The breakpoint joining the limbs of the control curve was right atrial pressure 3.4 +/- 1.2 mmHg and SV 1.5 +/- 0.4 ml X kg-1. Increased AP shifted the breakpoint downward. Linear regression of SV on AP from 15 to 95 mmHg at right atrial pressure greater than breakpoint was SV = -0.016 ml X kg-1 mmHg-1 X AP + 2.25 ml X kg-1.