THE DIM LIGHT MELATONIN ONSET AS A MARKER FOR CIRCADIAN PHASE POSITION
THE DIM LIGHT MELATONIN ONSET AS A MARKER FOR CIRCADIAN PHASE POSITION
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DOI：
10.3109/07420528909059144
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发表时间：
1989-01-01
影响因子：
2.8
通讯作者：
SACK, RL
中科院分区：
文献类型：
--
作者：
LEWY, AJ;SACK, RL
掩蔽已知会影响多种昼夜节律，因此很难将其用作昼夜节律相位位置的可靠标记。褪黑素可能是独特的，因为它似乎只被（明亮的）光线掩盖。睡眠和活动似乎不会影响褪黑激素的节律。通过测量褪黑激素产生的开始，一个明确界定的事件，我们可以可靠地评估昼夜节律相位位置，提供血液在昏暗的光线下取样（昏暗的褪黑激素开始，或DLMO）。DLMO在评估强光的相移特性和对患有时间生物学疾病（如冬季抑郁症）的患者进行相分型方面非常有用。
Masking is known to affect a variety of circadian rhythms, making it difficult to use them as reliable markers of circadian phase position. Melatonin may be unique in that it appears to be masked only by (bright) light. Sleep and activity do not appear to influence the melatonin rhythm. By measuring the onset of melatonin production, a clearly demarcated event, we can reliably assess circadian phase position, provided blood is sampled under dim light (the dim light melatonin onset, or DLMO). The DLMO has been useful in assessing the phase-shifting properties of bright light and in phase typing patients with chronobiologic disorders, such as winter depression.