Bioactive triterpene saponins from the roots of Phytolacca americana
Bioactive triterpene saponins from the roots of Phytolacca americana
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DOI：
10.1021/np078012m
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发表时间：
2008-01-01
影响因子：
5.1
通讯作者：
Ando, Masayoshi
中科院分区：
文献类型：
--
作者：
Wang, Liyan;Bai, Lin-Ting;Ando, Masayoshi
从美洲商陆根中分离出五种新的三萜皂苷，命名为商陆皂苷 N-1 (1)、N-2 (2)、N-3 (3)、N-4 (4) 和 N-5 (5)，以及七种已知的三萜皂苷 (6-12)。根据光谱数据，建立了五种新皂苷的结构，如结构1-5所示。基于在每种化合物存在下MDR人卵巢癌2780 AD细胞中累积的钙黄绿素的量评估1-12的MDR逆转活性。最有效的化合物是 8（25 μg/mL 时对照的 155%）。
Five new triterpene saponins named phytolaccasaponins N-1 (1), N-2 (2), N-3 (3) N-4 (4), and N-5 (5) were isolated from the roots of Phytolacca americana together with seven known triterpene saponins (6-12). The structures of the five new saponins were established as shown in structures 1-5 on the basis of their spectroscopic data. The MDR-reversal activity of 1-12 was evaluated on the basis of the amount of calcein accumulated in MDR human ovarian cancer 2780 AD cells in the presence of each compound. The most effective compound was 8 (155% of control at 25 mu g/mL).