Tanshinone IIA: A Promising Natural Cardioprotective Agent.
Tanshinone IIA: A Promising Natural Cardioprotective Agent.
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DOI：
10.1155/2012/716459
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Huang L
中科院分区：
文献类型：
--
作者：
Shang Q;Xu H;Huang L
丹参酮IIA（Tan IIA）是从丹参（Salvia miltiorrhiza Bunge）根中提取的主要亲脂性成分之一，目前在中国和其他邻国用于治疗心肌梗死（MI）、心绞痛、中风、糖尿病、败血症和其他病症。但是，Tan IIA不易通过肠道途径吸收。为提高丹参的生物利用度，研制了丹参酮IIA磺酸钠（STS）。本文讨论了Tan IIA、STS的药理学及其潜在的心脏保护作用。
Tanshinone IIA (Tan IIA) is a member of the major lipophilic components extracted from the root of Salvia miltiorrhiza Bunge, which is currently used in China and other neighboring countries to treat patients suffering from myocardial infarction (MI), angina pectoris, stroke, diabetes, sepsis, and other conditions. However, Tan IIA is not easy to be absorbed through intestinal pathway. To raise the bioavailability of the herb, sodium tanshinone IIA sulfonate (STS) was developed. This paper discussed the pharmacology of Tan IIA, STS, and their potential cardioprotective effects.