Galactokinase: Evidence for a New Racial Polymorphism
Galactokinase: Evidence for a New Racial Polymorphism
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半乳糖激酶：新种族多态性的证据
作者：
T. Tedesco;R. Bonow;K. Miller;W. Mellman
在 645 名孕妇的混合种族群体中测定了红细胞中半乳糖激酶和半乳糖-1-磷酸尿苷基转移酶的活性。黑人受试者的个体转移酶活性分布与白人相同。相比之下，黑人和白人个体半乳糖激酶活性的分布存在显着差异，黑人群体的平均值比白人群体的平均值低 30%。当检查男性和新生儿的红细胞半乳糖激酶活性时，发现了同样的种族差异。由于低、中和高半乳糖激酶活性似乎在几个黑人家族中存在分离，这种观察到的差异表明存在一种新的、由种族决定的酶多态性。
Activities of galactokinase and galactose-1-phosphate uridyltransferase in red cells were assayed in a mixed racial population of 645 pregnant women. The distribution of individual transferase activities for black subjects was the same as that for whites. In contrast, the distributions of individual galactokinase activities differed significantly in blacks and whites, the mean for the black population being 30 percent lower than the mean for the white population. The same racial difference was found when red cell galactokinase activity was examined in males and in newborns. Because low-, intermediate-, and high-galactokinase activities appear to segregate within several black families, this observed difference suggests a new, racially determined enzyme polymorphism.