Molecular diversity of neocortical GABAergic interneurones
Molecular diversity of neocortical GABAergic interneurones
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DOI：
10.1113/jphysiol.2004.078584
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发表时间：
2005-01-01
影响因子：
5.5
通讯作者：
Monyer, H
中科院分区：
文献类型：
--
作者：
Blatow, M;Caputi, A;Monyer, H
除了是成年大脑中抑制的主要来源外，GABA能中间神经元还有助于调节大型主细胞群的活动。GABA能中间神经元具有独特的功能，使它们能够促进同步网络活动的产生，从而塑造主要细胞行为。尽管在过去的几十年中，已经广泛研究了某些神经元间类型的解剖学和生理学特征，但神经元间的分子多样性是该领域最近的研究焦点。在许多受体家族的分子克隆和表达分析中，经常发现GABA在神经元和锥体细胞中的差异表达。在这里，我们回顾了最近的研究结果，在新皮层的GABA能神经元的分子多样性。更好地了解GABA能中间神经元中差异基因表达是进一步研究的基础，旨在了解中间神经元中特定蛋白质对网络功能的贡献。
In addition to being the main source of inhibition in the adult brain, GABAergic interneurones are instrumental in pacing the activity of large ensembles of principal cells. GABAergic interneurones have unique features that enable them to contribute to the generation of synchronized network activity thereby shaping principal cell behaviour. Whereas the anatomical and physiological characteristics of certain interneuronal types have been studied extensively over the last decades, the molecular diversity of interneurones is a more recent focus of investigation in this field. Molecular cloning and expression g in analysis of many receptor families often revealed differential expression in GABAeraric inter-neurones and pyramidal cells. Here we review recent findings regarding the molecular diversity of GABAergic interneurones in the neocortex. Better knowledge about differential gene expression in GABAergic interneurones is the basis for further investigations aimed at understanding the contribution of specific proteins in interneurones to network function.