Cancer stem cells, cancer cell plasticity and radiation therapy.
Cancer stem cells, cancer cell plasticity and radiation therapy.
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DOI：
10.1016/j.semcancer.2014.07.001
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发表时间：
2015-04
影响因子：
14.5
通讯作者：
Pajonk F
中科院分区：
文献类型：
--
作者：
Vlashi E;Pajonk F
自从第一次在实体癌中前瞻性地鉴定出癌症干细胞以来，癌症干细胞假说已经重新成为越来越感兴趣的研究课题。它假设实体癌是分层组织的，其中少量癌症干细胞驱动肿瘤生长，损伤和转移后再增殖。它们产生分化的后代，而后代缺乏这些特征。该模型预测，对于任何提供治愈的疗法，必须消除所有癌症干细胞，而分化后代的存活则不那么重要。在这篇综述中，我们讨论了最近的报告挑战的想法，单向分化的癌细胞。这些报告提供的证据支持了这样一种观点，即非干细胞癌细胞表现出显着的可塑性，使它们能够重新获得癌症干细胞特征，特别是在放射治疗的背景下。我们总结了分化逆转的条件，并讨论了目前的知识的基本机制。
Since the first prospective identification of cancer stem cells in solid cancers the cancer stem cell hypothesis has reemerged as a research topic of increasing interest. It postulates that solid cancers are organized hierarchically with a small number of cancer stem cells driving tumor growth, repopulation after injury and metastasis. They give rise to differentiated progeny, which lack these features. The model predicts that for any therapy to provide cure, all cancer stem cells have to be eliminated while the survival of differentiated progeny is less critical. In this review we discuss recent reports challenging the idea of a unidirectional differentiation of cancer cells. These reports provide evidence supporting the idea that non-stem cancer cells exhibit a remarkable degree of plasticity that allows them to re-acquire cancer stem cell traits, especially in the context of radiation therapy. We summarize conditions under which differentiation is reversed and discuss the current knowledge of the underlying mechanisms.
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影响因子：
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