Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the PreBotzinger complex
Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the PreBotzinger complex
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DOI：
10.1126/science.286.5444.1566
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发表时间：
1999-11-19
期刊：
影响因子：
56.9
通讯作者：
Feldman, JL
中科院分区：
文献类型：
--
作者：
Gray, PA;Rekling, JC;Feldman, JL
神经动素-1受体（NK1R）和mu-阿片受体（mu OR）激动剂直接注射到预先波齐格复合物（preBotzinger Complex，哺乳动物呼吸节律发生的假设部位）时，会影响呼吸节律。这些作用是通过对bot前节律性神经元的作用介导的。NK1R（+）神经元的分布在解剖学上定义了preBotC。preBotC中的1型神经元具有节律性，同时表达NK1Rs和mu ORs，而2型神经元仅表达NK1Rs。这些发现表明，preBotC是一种可定义的解剖结构，具有独特的生理功能，同时表达NK1Rs和mu ORs的神经元亚群产生呼吸节律并调节呼吸频率。
Neurokinin-1 receptor (NK1R) and mu-opioid receptor (mu OR) agonists affected respiratory rhythm when injected directly into the preBotzinger Complex (preBotC), the hypothesized site for respiratory rhythmogenesis in mammals. These effects were mediated by actions on preBotC rhythmogenic neurons. The distribution of NK1R(+) neurons anatomically defined the preBotC. Type 1 neurons in the preBotC, which have rhythmogenic properties, expressed both NK1Rs and mu ORs, whereas type 2 neurons expressed only NK1Rs. These findings suggest that the preBotC is a definable anatomic structure with unique physiological function and that a subpopulation of neurons expressing both NK1Rs and mu ORs generate respiratory rhythm and modulate respiratory frequency.