Alcohol consumption and alcohol pharmacokinetics: interactions within the normal population.
Alcohol consumption and alcohol pharmacokinetics: interactions within the normal population.
复制标题
饮酒和酒精药代动力学：正常人群内的相互作用。
DOI：
--
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
N. Martin
中科院分区：
文献类型：
--
作者：
J. Whitfield;N. Martin
我们分析了一组199名男性和213名女性双胞胎的习惯性饮酒，标准剂量后血液酒精浓度峰值和酒精代谢率之间的相互关系。峰值浓度和代谢率与酒精消费水平密切相关，即使在0-10克酒精/天的范围内。男性和女性的峰值浓度和代谢率密切相关;这不是由于他们对酒精摄入的共同依赖，也不是由于实验误差。这些结果表明，习惯性消费对酒精药代动力学的影响的阈值远低于以前的怀疑，并有因素，减少吸收前或首过代谢，但增加吸收后代谢。
We have analyzed the interrelationships between habitual alcohol consumption, peak blood alcohol concentration after a standard dose, and rate of alcohol metabolism in a group of 199 male and 213 female twins. Both peak concentration and rate of metabolism are strongly associated with alcohol consumption levels, even in the range of 0-10 g of alcohol/day. The peak concentration and rate of metabolism were strongly correlated in both men and women; this is not due to their common dependence on alcohol intake nor to experimental error. These results show that the threshold for effects of habitual consumption on alcohol pharmacokinetics is much lower than previously suspected, and that there are factors that reduce preabsorptive or first-pass metabolism but increase postabsorptive metabolism.
影响因子：
2.9
作者：
W. F. Bosron;L. Magnes;T. Li
通讯作者：
W. F. Bosron;L. Magnes;T. Li
人胃乙醇脱氢酶：H2 受体拮抗剂的抑制作用及其对乙醇生物利用度的影响。
DOI：
10.1111/j.1530-0277.1990.tb01843.x
发表时间：
1990
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Hernández-Muñoz,R;Caballeria,J;Baraona,E;Uppal,R;Greenstein,R;Lieber,CS
通讯作者：
Lieber,CS
DOI：
--
发表时间：
1983
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Nomura,F;Pikkarainen,PH;Jauhonen,P;Arai,M;Gordon,ER;Baraona,E;Lieber,CS
通讯作者：
Lieber,CS