Adjuvanticity and arthritogenicity of silicone.
Adjuvanticity and arthritogenicity of silicone.
复制标题
有机硅的佐剂性和致关节炎性。
DOI：
10.1097/00006534-199309000-00014
复制
发表时间：
1993
影响因子：
3.6
通讯作者：
Chang,YH
中科院分区：
文献类型：
--
作者：
Chang,YH
从乳房植入物中获得的硅胶的潜在佐剂性和关节炎性进行了研究。将硅胶与热杀灭结核分枝杆菌和EL 4细胞（小鼠肿瘤细胞，h - 2b）一起腹腔注射，未能增强Lewis大鼠针对EL 4细胞的免疫应答的发展。足底注射硅胶，单独或与热杀结核分枝杆菌联合，也未能诱导Lewis大鼠佐剂性关节炎。这些发现表明，硅酮既没有佐剂活性，也没有关节炎的性质，不能有效地替代弗氏佐剂中的矿物油成分。Reconstr。外科杂志92:469,1993。)
Potential adjuvanticity and arthritogenicity of silicone obttained from a mammary implant were investigated. Silicone, injected intraperitoneally in conjunction with heat-killed Mycobacterium tuberculosis and EL 4 cells (mouse tumor cell, H-2 b), failed to enhance the development of immune response directed toward EL 4 cells in Lewis rats. Subplantar injection of silicone, alone or in combination with heat-killed M. tuberculosis, also failed to induce adjuvant arthritis in Lewis rats. These findings suggest that silicone has neither adjuvant activity nor arthritogenic property and is not an effective substitute for the mineral oil component of Freund's adjuvant.(Plast. Reconstr. Surg. 92: 469, 1993.)