Navigation-specific neural coding in the visual system of Drosophila
Navigation-specific neural coding in the visual system of Drosophila
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DOI：
10.1016/j.biosystems.2015.07.008
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发表时间：
2015-10-01
期刊：
影响因子：
1.6
通讯作者：
Philippides, Andrew
中科院分区：
文献类型：
--
作者：
Dewar, Alex D. M.;Wystrach, Antoine;Philippides, Andrew
黑腹果蝇是一个很好的系统，可以用来理解广泛的视觉引导行为的最低要求，比如导航，因为它们的大脑很小(成年人只有10万个神经元)，而且可以利用神经遗传学技术来识别特定任务的细胞类型。最近发表的数据描述了两类视觉反应神经元(中央复合体中的R2和R3/R4D环神经元)的感受野，这两类神经元对视觉任务至关重要，如对显著物体的定向记忆和简单的模式辨别。有趣的是，这些细胞具有非常大的感受野，数量非常少，这表明每个细胞亚群可能是处理特定行为的视觉信息的瓶颈，因为每个细胞亚群有效地将眼睛中大约3000个视觉感受器的信息浓缩到总共不到50个神经元。最近研究表明，RI环神经元与R2和R3/R4D细胞从相同的区域接受输入，是果蝇位置学习所必需的。然而，R1神经元是如何实现位置学习的尚不清楚。通过检验不同群体的假想视觉神经元在模拟实验场中提供的信息，我们表明，具有环形神经元样感受野的神经元足以在视觉上定义一个位置。通过这种方式，我们提供了环状神经元所传达的信息类型与它们所支持的行为之间的联系。(C)2015爱思唯尔爱尔兰有限公司。保留所有权利。
Drosophila melanogaster are a good system in which to understand the minimal requirements for widespread visually guided behaviours such as navigation, due to their small brains (adults possess only 100,000 neurons) and the availability of neurogenetic techniques which allow the identification of task-specific cell types. Recently published data describe the receptive fields for two classes of visually responsive neurons (R2 and R3/R4d ring neurons in the central complex) that are essential for visual tasks such as orientation memory for salient objects and simple pattern discriminations. What is interesting is that these cells have very large receptive fields and are very small in number, suggesting that each sub-population of cells might be a bottleneck in the processing of visual information for a specific behaviour, as each subset of cells effectively condenses information from approximately 3000 visual receptors in the eye, to fewer than 50 neurons in total. It has recently been shown how RI ring neurons, which receive input from the same areas as the R2 and R3/R4d cells, are necessary for place learning in Drosophila. However, how R1 neurons enable place learning is unknown. By examining the information provided by different populations of hypothetical visual neurons in simulations of experimental arenas, we show that neurons with ring neuron-like receptive fields are sufficient for defining a location visually. In this way we provide a link between the type of information conveyed by ring neurons and the behaviour they support. (C) 2015 Elsevier Ireland Ltd. All rights reserved.