AGE-DEPENDENT EFFECT OF RESISTANCE EXERCISE ON GROWTH-HORMONE SECRETION IN PEOPLE
AGE-DEPENDENT EFFECT OF RESISTANCE EXERCISE ON GROWTH-HORMONE SECRETION IN PEOPLE
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DOI：
10.1210/jc.75.2.404
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发表时间：
1992-08-01
影响因子：
5.8
通讯作者：
MARCUS, R
中科院分区：
文献类型：
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作者：
PYKA, G;WISWELL, RA;MARCUS, R
我们测量了12名年轻受试者（6男6女; 27 +/- 1.6岁）和11名老年人（6男5女; 72 +/- 0.8岁）对标准化抗阻运动回路的血清GH反应。使用Nautilus设备对12个肌肉群进行力量[1次重复最大值（1 RM）]的初始评估。一周后，受试者进行运动方案，12项运动中的每项运动重复3组8次，预定的1 RM值为70%。在基线时、每次运动后和10分钟恢复期内每2分钟抽取静脉血。在年轻的受试者血清免疫反应性生长激素上升完成第二次运动，增加，并保持在运动期间的剩余时间升高，并下降到基线的10分钟的恢复。在老年受试者中，基线GH值与年轻受试者相似（1.76 +/- 0.41 vs. 2.61 +/- 0.73 μ g/L），并且在运动期间或运动后的任何时间均未增加至6 μ g/L以上。运动增加了两组的GH，但年轻受试者的峰值（年轻人14.9 +/- 3.5 μ g/L;老年人2.44 +/- 0.6 μ g/L）和综合值（年轻人198 +/- 47;老年人37.8 +/- 0.8）显著更高（P < 0.05）。GH反应在两组中均无性别差异。在个别运动中观察到脉率短暂增加，但没有发生持续升高。为了评估运动强度对GH反应的影响，我们比较了7名年轻人和11名老年人在70%和85%的1 RM运动时的反应。在年轻受试者中，GH反应在60%时不显著，并在1 RM的70%和85%时逐渐增加。在老年受试者中没有观察到运动强度的显著影响。我们的结论是，阻力运动迅速提高循环GH浓度在健康的年轻人。这种反应与阻力刺激的强度有关，尽管不能排除有氧应激的小贡献。健康的老年男性和女性的GH抵抗活动的反应明显减少。
We measured serum GH responses to a standardized circuit of resistance exercise in 12 young subjects (6 men and 6 women; 27 +/- 1.6 yr old) and in 11 elders (6 men and 5 women; 72 +/- 0.8 yr old). Initial assessment of strength [1 repetition maximum (1RM)] was made of 12 muscle groups using Nautilus equipment. One week later, subjects carried out the exercise protocol, 3 sets of 8 repetitions for each of the 12 exercises, at 70% of predetermined 1RM values. Venous blood was drawn at baseline, after each exercise, and every 2 min during 10 min of recovery. In young subjects serum immunoreactive GH rose by completion of the second exercise, increased and remained elevated through the remainder of the exercise period, and decreased toward baseline by 10 min of recovery. In the elderly subjects, baseline GH values were similar to those in the young (1.76 +/- 0.41 vs. 2.61 +/- 0.73-mu-g/L) and did not increase above 6-mu-g/L at any time during or after exercise. Exercise increased GH in both groups, but peak values (14.9 +/- 3.5-mu-g/L in young; 2.44 +/- 0.6-mu-g/L in old) and integrated (198 +/- 47 in young; 37.8 +/- 0.8 in old) were significantly greater in the young subjects (P < 0.05). GH responses showed no gender difference in either group. Brief increases in pulse rate were observed during individual exercises, but sustained elevations did not occur. To assess the effect of exercise intensity on GH response, we compared responses to exercise at 70% and 85% of 1RM in 7 young and 11 older people. In the young subjects, GH responses were nonsignificant at 60% and increased progressively at 70% and 85% of 1RM. No significant effect of exercise intensity was observed in the older subjects. We conclude that resistance exercise promptly elevates circulating GH concentrations in healthy young adults. This response is related to the intensity of the resistance stimulus, although a small contribution of aerobic stress cannot be excluded. The GH response to resistance activity is grossly diminished in healthy elderly men and women.