Modeling the mechanical properties of liver fibrosis in rats
Modeling the mechanical properties of liver fibrosis in rats
复制标题
模拟大鼠肝纤维化的机械特性
DOI：
10.1016/j.jbiomech.2016.03.013
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发表时间：
2016
影响因子：
2.4
通讯作者：
Song Liang
中科院分区：
文献类型：
--
作者：
Zhu Ying;Chen Xin;Zhang Xinyu;Chen Siping;Shen Yuanyuan;Song Liang
肝纤维化的进展改变了肝组织的生物力学特性。本研究的特点和比较不同阶段的大鼠肝纤维化的粘弹性。三个粘弹性模型，Voigt，麦克斯韦，和齐纳模型，应用于流变仪测试的实验数据，然后估计每个纤维化阶段的弹性和粘度。研究发现，弹性和粘度都与肝纤维化的各个阶段相关。研究表明，Zener模型是描述各纤维化阶段力学特性的最佳模型，但Zener和Voigt模型在肝纤维化分期方面的性能无显著差异。因此，Voigt模型仍然可以有效地用于肝纤维化分级。
The progression of liver fibrosis changes the biomechanical properties of liver tissue. This study characterized and compared different liver fibrosis stages in rats in terms of viscoelasticity. Three viscoelastic models, the Voigt, Maxwell, and Zener models, were applied to experimental data from rheometer tests and then the elasticity and viscosity were estimated for each fibrosis stage. The study found that both elasticity and viscosity are correlated with the various stages of liver fibrosis. The study revealed that the Zener model is the optimal model for describing the mechanical properties of each fibrosis stage, but there is no significant difference between the Zener and Voigt models in their performance on liver fibrosis staging. Therefore the Voigt model can still be effectively used for liver fibrosis grading.