Immunization against IGF-I prevents increases in protein synthesis in diabetic rats after resistance exercise.
Immunization against IGF-I prevents increases in protein synthesis in diabetic rats after resistance exercise.
复制标题
针对 IGF-I 的免疫可防止糖尿病大鼠在抗阻运动后蛋白质合成的增加。
DOI：
10.1152/ajpendo.2001.280.6.e877
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Farrell,PA
中科院分区：
文献类型：
--
作者：
Fedele,MJ;Lang,CH;Farrell,PA
These studies examined whether passive immunization against insulin-like growth factor I (IGF-I) would prevent increases in rates of protein synthesis in skeletal muscle of diabetic rats after resistance exercise. Male Sprague-Dawley rats were pancreatectomized and randomly assigned to either an exercise or a sedentary group. Animals in each of these groups received either an IGF-I antibody or a nonspecific IgG from a subcutaneous osmotic pump. Exercise did not change plasma or gastrocnemius IGF-I concentrations in nondiabetic rats. However, plasma and muscle IGF-I concentrations were higher in IgG-treated diabetic rats that exercised compared with respective sedentary groups (P< 0.05). Passively immunized diabetic rats did not exhibit the same exercise-induced increase in IGF-I concentrations. In nondiabetic rats, protein synthesis rates were higher after exercise in both control and immunized groups. In diabetic rats, exercise increased protein synthesis in the IgG-treated animals but not in those treated with IGF-I antibody. There was also a significant positive correlation between both plasma and gastrocnemius IGF-I concentrations and rates of protein synthesis in diabetic (P< 0.01), but not nondiabetic, rats. These results suggest that IGF-I is compensatory for insulin in hypoinsulinemic rats by facilitating an anabolic response after acute resistance exercise.
