Silent spread of H5N1 in vaccinated poultry
Silent spread of H5N1 in vaccinated poultry
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DOI：
10.1038/442757a
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发表时间：
2006-08-17
期刊：
影响因子：
64.8
通讯作者：
Woolhouse, Mark E. J.
中科院分区：
文献类型：
--
作者：
Savill, Nicholas J.;St Rose, Suzanne G.;Woolhouse, Mark E. J.
国际上对接种H5N1甲型流感病毒疫苗的利弊进行了辩论，这引起了人们对在发现疫情之前可能增加鸡群间传播风险的担忧。在这里，我们表明，这种“无声的传播”可以发生，因为在羊群水平的不完全保护，即使疫苗是有效的个别鸟类。使用未接种疫苗的哨兵可以减轻，但不能完全消除，这个问题。
International debate on the merits of vaccinating poultry against the H5N1 influenza A virus,,has raised concerns about the possibility of an increased risk of between-flock transmission before outbreaks are detected. Here we show that this 'silent spread' can occur because of incomplete protection at the flock level, even if a vaccine is effective in individual birds. The use of unvaccinated sentinels can mitigate, although not completely eliminate, the problem.