Chronic thyrotropin releasing hormone (TRH) administration on TRH receptors and muscarinic cholinergic receptors in CNS
Chronic thyrotropin releasing hormone (TRH) administration on TRH receptors and muscarinic cholinergic receptors in CNS
复制标题
长期施用促甲状腺素释放激素 (TRH) 对 CNS 中 TRH 受体和毒蕈碱胆碱能受体的影响
DOI：
10.1016/0006-8993(83)90328-1
复制
发表时间：
1983
期刊：
影响因子：
2.9
通讯作者：
A. Mori
中科院分区：
文献类型：
--
作者：
N. Ogawa;S. Mizuno;I. Nukina;S. Tsukamoto;A. Mori
给大鼠腹腔注射促甲状腺激素释放激素（TRH，6 mg/kg/d）14天，可使海马、下丘脑和大脑皮质TRH结合位点明显丢失（20-25%）。TRH介导的损失是可逆的，反映了结合位点的减少，但亲和力没有变化。另一方面，这种TRH处理不影响[3 H]QNB的特异性脑结合。结果提示TRH参与调节CNS-TRH受体。
Intraperitoneal injections of thyrotropin releasing hormone (TRH, 6 mg/kg/day) to rats for 14 days resulted in a significant loss (20–25%) of TRH binding sites in the hippocampus, hypothalamus and cerebral cortex. The TRH-mediated loss was reversible and reflected a decrease in binding sites but no change in affinity. On the other hand, this TRH treatment did not affect the specific brain binding of [3H]QNB. The results suggest that TRH participates in regulating CNS-TRH receptors.