Cruciferous and Allium Vegetable Intakes are Inversely Associated With 15-Year Atherosclerotic Vascular Disease Deaths in Older Adult Women
Cruciferous and Allium Vegetable Intakes are Inversely Associated With 15-Year Atherosclerotic Vascular Disease Deaths in Older Adult Women
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DOI：
10.1161/jaha.117.006558
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发表时间：
2017-10-01
影响因子：
5.4
通讯作者：
Hodgson, Jonathan M.
中科院分区：
文献类型：
--
作者：
Blekkenhorst, Lauren C.;Bondonno, Catherine P.;Hodgson, Jonathan M.
背景：较高的蔬菜摄入量始终与较低的动脉粥样硬化性血管疾病（ASVD）事件相关。然而，负责的组成部分和涉及的机制是不确定的。可能涉及非营养性植物化学物质。本研究的目的是调查总蔬菜摄入量和根据植物化学成分分组的蔬菜类型与ASVD死亡率的关系。方法和结果：该队列包括1226名澳大利亚女性，年龄在70岁及以上，基线时无临床ASVD或糖尿病（1998年）。计算每份蔬菜的摄入量（75克/天），并根据植物化学成分预先分类。asvd相关死亡是根据相关死亡率数据确定的。在15年（15947人年）的随访期间，发生了238例asvd相关死亡。每增加1份蔬菜摄入量，asvd相关死亡风险降低20%（多变量校正风险比为0.80；95%可信区间为0.69-0.94 [P=0.005]）。在蔬菜类型的多变量调整模型中，十字花科（每10克/天增加）：风险比为0.87；95%置信区间为0.81-0.94
Background-Higher vegetable intake is consistently associated with lower atherosclerotic vascular disease (ASVD) events. However, the components responsible and mechanisms involved are uncertain. Nonnutritive phytochemicals may be involved. The objective of this study was to investigate the associations of total vegetable intake and types of vegetables grouped according to phytochemical constituents with ASVD mortality.Methods and Results-The cohort consisted of 1226 Australian women aged 70 years and older without clinical ASVD or diabetes mellitus at baseline (1998). Vegetable intakes were calculated per serving (75 g/d) and were also classified into prespecified types relating to phytochemical constituents. ASVD-related deaths were ascertained from linked mortality data. During 15 years (15 947 person-years) of follow-up, 238 ASVD-related deaths occurred. A 1-serving increment of vegetable intake was associated with a 20% lower hazard of ASVD-related death (multivariable-adjusted hazard ratio, 0.80; 95% confidence interval, 0.69-0.94 [P=0.005]). In multivariable-adjusted models for vegetable types, cruciferous (per 10-g/d increase: hazard ratio, 0.87; 95% confidence interval, 0.81-0.94 [P