TEP SNORD12B, SNORA63, and SNORD14E as novel biomarkers for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC).
TEP SNORD12B, SNORA63, and SNORD14E as novel biomarkers for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC).
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DOI：
10.1186/s12935-023-03179-z
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发表时间：
2024-01-02
影响因子：
5.8
通讯作者：
Song, Xingguo
中科院分区：
文献类型：
--
作者：
Zhao, Xuan;Chen, Guanxuan;Wu, Yawen;Li, Xiao;Zhang, Zhe;Xie, Li;Song, Xianrang;Song, Xingguo
肿瘤诱导血小板（TEPs）中RNA谱的改变已被描述为用于癌症诊断的新生物来源。本研究旨在探讨TEP中snoRNA作为诊断B病毒相关肝细胞癌（HBV相关HCC）的生物标志物的可能性。使用低速离心分离血小板，并进行定量聚合酶链反应（qPCR）用于snoRNA检测。SNORD 12 B和SNORD 14 E在HBV相关HCC的TEP中表达下调，SNORA 63表达上调，可作为HBV相关HCC及早期疾病的诊断标志物。此外，TEP SNORD 12 B、SNORD 14 E和SNORA 63有助于AFP的诊断性能，并且当与血小板参数组合时，对HBV相关的HCC实现有利的诊断效率。SNORD 12 B、SNORA 63和SNORD 14 E在TEPs中的异常表达可作为HBV相关HCC诊断的新的非侵入性生物标志物。在线版本包含补充材料，可通过10.1186/s12935-023-03179-z获得。
The alterations of RNA profile in tumor-educated platelets (TEPs) have been described as a novel biosource for cancer diagnostics. This study aimed to explore the potential snoRNAs in TEP as biomarkers for diagnostics of hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC). Platelets were isolated using low-speed centrifugation and subjected to a quantitative polymerase chain reaction (qPCR) for snoRNAs detection. Down-regulated SNORD12B and SNORD14E as well as up-regulated SNORA63 were identified in TEP from HBV-related HCC, which could act as diagnostic biomarkers for HBV-related HCC as well as the early disease. Besides, TEP SNORD12B, SNORD14E, and SNORA63 facilitate the diagnostic performance of AFP and achieve favorable diagnostics efficiency for HBV-related HCC when combined with platelet parameters. Aberrant expression of SNORD12B, SNORA63, and SNORD14E in TEPs could serve as the novel and non-invasive biomarkers for HBV-related HCC diagnosis. The online version contains supplementary material available at 10.1186/s12935-023-03179-z.
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影响因子：
13.3
作者：
Chouhan, Surbhi;Sawant, Mithila;Weimholt, Cody;Luo, Jingqin;Sprung, Robert W.;Terrado, Mailyn;Mueller, David M.;Earp, H. Shelton;Mahajan, Nupam P.
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Goel A
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影响因子：
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16.6
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通讯作者：
Mahajan, Nupam P.