Desymmetrization of aziridine with malononitrile using cinchona alkaloid amide/zinc(II) catalysts
Desymmetrization of aziridine with malononitrile using cinchona alkaloid amide/zinc(II) catalysts
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DOI：
10.1039/c6cc09457k
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发表时间：
2017-02-07
影响因子：
4.9
通讯作者：
Nakamura, Shuichi
中科院分区：
文献类型：
--
作者：
Shiomi, Noriyuki;Kuroda, Mami;Nakamura, Shuichi
研究了丙二腈催化氮杂环丙烷对映体选择性脱对称化反应。金鸡纳生物碱酰胺/锌(II)催化剂具有较好的产率和对映体选择性。所得产物可转化为β-氨基酸酯、β-氨基酰胺和三酰胺类化合物。
The catalytic enantioselective desymmetrization of aziridines with malononitrile has been developed. Good yield and enantioselectivity were obtained by using cinchona alkaloid amide/Zn(II) catalysts. The obtained product can be converted to beta-aminoester, beta-aminoamide and triamide compounds.