IN VIVO AND IN VITRO CHROMOSOMAL DAMAGE INDUCED BY LSD-25
IN VIVO AND IN VITRO CHROMOSOMAL DAMAGE INDUCED BY LSD-25
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DOI：
10.1056/nejm196711162772001
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发表时间：
1967-01-01
影响因子：
158.5
通讯作者：
FROSCH, WA
中科院分区：
文献类型：
--
作者：
COHEN, MM;HIRSCHHO.K;FROSCH, WA
由外源因子，如病毒、辐射和化学物质诱导染色体畸变，是细胞遗传学研究的一个活跃领域。1最近，拟精神病致幻剂麦角酰二乙胺（LSD-25）已被添加到能够引起人类白细胞染色体异常的化学物质清单中。2，3这些初步研究报告了LSD的体外和体内染色体效应，材料和方法体外培养6例正常健康人（3例男性，3例女性）外周血白细胞培养，其中1例为正常人，1例为正常人，2例为正常人，3例为正常人，3例为正常人。
THE induction of chromosomal aberrations by exogenous agents, such as viruses, radiation and chemicals, is an area of active cytogenetic investigation.1Recently, the psychotomimetic hallucinogen, lysergic acid diethylamide (LSD-25), has been added to the list of chemicals capable of causing abnormalities in the chromosomes of human leukocytes.2,3Such preliminary studies report the in vitro and in vivo chromosomal effects of LSD, and the present communication extends these observations to include additional in vitro findings and a significant sample of patients.Materials and MethodsIn Vitro StudiesPeripheral leukocyte cultures were initiated from 6 normal, healthy persons (3 males and 3 . . .