Laser fabrication of high aspect ratio thin holes on biodegradable polymer and its application to a microneedle
Laser fabrication of high aspect ratio thin holes on biodegradable polymer and its application to a microneedle
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DOI：
10.1016/j.sna.2006.11.022
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发表时间：
2007-09-12
影响因子：
4.6
通讯作者：
Ogawa, Hiroshi
中科院分区：
文献类型：
--
作者：
Aoyagi, Seiji;Izumi, Hayato;Ogawa, Hiroshi
本文报道了利用紫外准分子激光在可生物降解高分子材料（聚乳酸，本文简称为PLA）上制备高宽高比为100（直径10 μ m，深度1 mm）的细长孔。从PLA片材的侧面制备直径为10、20和50 μ m的孔，并使用光学显微镜观察其制备形状。这些孔与其他聚合物片上的孔进行了比较。结果表明，与环氧树脂材料相比，聚乳酸材料可以制造出细长的孔，但制造速度较慢。将激光加工技术应用于聚乳酸微针的制备。沿着微针的中心线制作了一个孔，实验证实了血浆通过毛细管力进入这个孔。(c) 2006 Elsevier B.V.版权所有
The present paper reports the fabrication of long thin holes with a high aspect ratio of 100 (diameter: 10 mu m, depth: I mm) in biodegradable polymer material (polylactic acid, referred to herein as PLA) using a UV excimer laser. Holes having diameters of 10, 20 and 50 mu m are fabricated from the side surface of a PLA sheet, and their fabricated shapes are observed using an optical microscope. These holes are compared with holes fabricated in other polymer sheets. It is proven that a long thin hole can be fabricated in PLA material, although at a lower fabrication rate compared that for epoxy material. This laser fabrication is applied to a PLA microneedle, which is fabricated by the micromolding technique. A hole is fabricated along the centerline of the newly developed microneedle, and it is confirmed experimentally that blood plasma is taken into this hole by capillary force. (c) 2006 Elsevier B.V. All rights reserved.