Inhibition of nuclear factor-κB impairs reconsolidation of morphine reward memory in rats
Inhibition of nuclear factor-κB impairs reconsolidation of morphine reward memory in rats
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DOI：
10.1016/j.bbr.2010.08.047
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发表时间：
2011-01-20
影响因子：
2.7
通讯作者：
Lu, Lin
中科院分区：
文献类型：
--
作者：
Yang, Jianli;Yu, Jingjie;Lu, Lin
药物成瘾是一个与突触可塑性有关的过程，在这个过程中，滥用药物会影响中脑边缘系统。先前的研究表明，药物滥用可以通过破坏与药物相关的记忆的重新巩固来抑制。核因子-kappaB在包括再巩固在内的记忆的不同阶段中起着重要的调节作用，但其在奖赏记忆再巩固中的作用尚未被研究。本研究的目的是研究核因子-kappaB在药物相关记忆再巩固中的作用。我们发现，大鼠获得了吗啡诱导的条件性位置偏爱，这种偏爱可被再次暴露于先前与吗啡配对的小室(即记忆恢复过程)后给予的核因子-kappa B抑制剂SN50抑制。全身注射组蛋白去乙酰酶抑制剂丁酸钠可逆转SN50对奖赏记忆再巩固的破坏作用。这些结果表明，SN50通过抑制核因子-kappaB而破坏与吗啡相关的记忆再巩固，这种作用可通过抑制组蛋白乙酰化而逆转。(C)2010爱思唯尔B.V.保留所有权利。
Drug addiction is a process associated with synaptic plasticity in which a drug of abuse affects the midbrain limbic system. Previous studies have indicated that drug abuse can be inhibited by disrupting the reconsolidation of a drug-related memory. Nuclear factor-kappa B (NF-kappa B) plays an important role in modulating different stages of memory, including reconsolidation, but its role in the reconsolidation of a reward memory has not been investigated. The aim of the present study was to examine the role of NF-kappa B in drug-related memory reconsolidation. We found that rats acquired morphine-induced conditioned place preference, which was inhibited by the NF-kappa B inhibitor SN50 administered after reexposure to a previously morphine-paired chamber (i.e., a memory retrieval process). The disruptive effect of SN50 on reward memory reconsolidation was reversed by systemic injections of the histone deacetylase inhibitor sodium butyrate. These results indicate that SN50 disrupts morphine-related memory reconsolidation by inhibiting NF-kappa B, and this effect can be reversed by inhibiting histone acetylation. (C) 2010 Elsevier B.V. All rights reserved.