Striatal function in relation to negative symptoms in schizophrenia
Striatal function in relation to negative symptoms in schizophrenia
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DOI：
10.1017/s003329171100119x
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发表时间：
2012-02-01
影响因子：
6.9
通讯作者：
Holt, D. J.
中科院分区：
文献类型：
--
作者：
Ehrlich, S.;Yendiki, A.;Holt, D. J.
背景先前的研究表明，执行功能的动机方面，这可能是在精神分裂症患者的阴性症状中断，部分介导的纹状体。阴性症状与纹状体和背外侧前额叶皮质（DLPFC）的招募受损有关。在这里，我们测试的假设，阴性症状主要与纹状体功能障碍，使用功能磁共振成像（fMRI）。采用感兴趣区（ROI）法测量了147名精神分裂症患者和160名健康对照者的工作记忆负荷依赖性激活和纹状体及DLPFC的灰质体积。除了检测纹状体功能和阴性症状之间的线性关系外，我们还选择了第二种分类分析策略，比较了三个人口统计学和行为学匹配的亚组：阴性症状负担高的患者、阴性症状最轻的患者和健康受试者。精神分裂症患者和健康对照组的纹状体反应幅度无差异，但患者的右侧DLPFC活性高于对照组。阴性症状与纹状体活性呈负相关，但与DLPFC活性无关。此外，与阴性症状轻微的精神分裂症患者相比，阴性症状负担高的患者双侧纹状体激活显著降低，但DLPFC没有。工作记忆表现、抗精神病药物暴露和灰质体积的变化不能解释这些差异。这些数据为阴性症状和纹状体活动减少之间的强相关性提供了进一步的证据。未来的工作将确定精神分裂症患者的低纹状体活性是否可以作为阴性症状的可靠生物标志物。收稿日期：2011年1月6日;修订日期：2011年5月20日;接受日期：2011年6月6日;首次在线发表日期：2011年7月7日
Background. Previous studies have suggested that motivational aspects of executive functioning, which may be disrupted in schizophrenia patients with negative symptoms, are mediated in part by the striatum. Negative symptoms have been linked to impaired recruitment of both the striatum and the dorsolateral prefrontal cortex (DLPFC). Here we tested the hypothesis that negative symptoms are associated primarily with striatal dysfunction, using functional magnetic resonance imaging (fMRI).Method. Working-memory load-dependent activation and gray matter volumes of the striatum and DLPFC were measured using a region-of-interest (ROI) approach, in 147 schizophrenia patients and 160 healthy controls. In addition to testing for a linear relationships between striatal function and negative symptoms, we chose a second, categorical analytic strategy in which we compared three demographically and behaviorally matched subgroups: patients with a high burden of negative symptoms, patients with minimal negative symptoms, and healthy subjects.Results. There were no differences in striatal response magnitudes between schizophrenia patients and healthy controls, but right DLPFC activity was higher in patients than in controls. Negative symptoms were inversely associated with striatal, but not DLPFC, activity. In addition, patients with a high burden of negative symptoms exhibited significantly lower bilateral striatal, but not DLPFC, activation than schizophrenia patients with minimal negative symptoms. Working memory performance, antipsychotic exposure and changes in gray matter volumes did not account for these differences.Conclusions. These data provide further evidence for a robust association between negative symptoms and diminished striatal activity. Future work will determine whether low striatal activity in schizophrenia patients could serve as a reliable biomarker for negative symptoms. Received 6 January 2011; Revised 20 May 2011; Accepted 6 June 2011; First published online 7 July 2011