Dysidiolide and related γ-hydroxy butenolide compounds as inhibitors of the protein tyrosine phosphatase, Cdc25
Dysidiolide and related γ-hydroxy butenolide compounds as inhibitors of the protein tyrosine phosphatase, Cdc25
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DOI：
10.1016/s0960-894x(99)00431-x
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发表时间：
1999-09-06
影响因子：
2.7
通讯作者：
Pal, K
中科院分区：
文献类型：
--
作者：
Blanchard, JL;Epstein, DM;Pal, K
在体外Cdc25实验中，对合成的和天然的底物对合成的二烯二烯内酯以及一些含有γ -羟基丁烯内酯片段的相关化合物进行了测试。与文献值在低微摩尔范围相反，我们观察到这些化合物对Cdc25磷酸酶的抑制活性只有毫摩尔。1999爱思唯尔科学有限公司版权所有。
Synthetic dysidiolide, as well as several related compounds containing a gamma-hydroxybutenolide moiety, were tested in in vitro Cdc25 assays against both synthetic and natural substrates. Contrary to literature values which are in the low micromolar range, we observe only millimolar inhibitory activity for these compounds versus Cdc25 phosphatase. (C) 1999 Elsevier Science Ltd. All rights reserved.