Intimate host-tumor interaction in the spontaneous reticulum cell sarcoma of SJL/J mice: is it an exceptional case?
Intimate host-tumor interaction in the spontaneous reticulum cell sarcoma of SJL/J mice: is it an exceptional case?
复制标题
SJL/J 小鼠自发性网织细胞肉瘤中宿主与肿瘤的密切相互作用：这是一个特例吗？
DOI：
10.1007/bf02918735
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Bonavida,B
中科院分区：
文献类型：
--
作者：
Bonavida,B
癌症生物学领域发展迅速，一些新的发展对疾病的预防和治疗产生了重大影响。由于人类学科研究的局限性，已经建立了用于研究的实验性肿瘤模型系统，为临床前试验和新研究领域的发展提供了必要的工具。虽然总的来说，实验肿瘤系统与人类自发性肿瘤并不相同或直接可比较，但他们的研究揭示了几个适用于人类的发现。此外，实验肿瘤模型系统具有独特的特性，并且这些特性中的每一个都可以独立于其他因素进行分析。这里描述的实验肿瘤模型系统展示了一种自发的小鼠肿瘤，它具有几个明显独特的特性，在许多方面是一个非常规的实验系统。本文简要回顾了SJL/J小鼠自发性网状细胞肉瘤(RCS)的几个已知特性。
The field of cancer biology has been progressing rapidly, and several new developments have made a significant impact on prevention and therapy of the disease. Because of the limitations imposed on human subject research, experimental tumor model systems have been established for investigation which provide the necessary tools for preclinical trials and the development of new areas of research. While, in general, experimental tumor systems are not identical or directly comparable to human spontaneous neoplasia, their study has nevertheless revealed several findings which have been applicable in man. Also, experimental tumor model systems are characterized by unique properties, and each of these properties can be analyzed independently of other factors. The experimental tumor model system to be described here presents a spontaneous murine tumor which has several apparently unique properties and is in many ways an unconventional experimental system. This brief review addresses several of the known properties of the spontaneous reticulum cell sarcoma (RCS) tumor in SJL/J mice.