Duration of Analgesic Use and Risk of Hearing Loss in Women
Duration of Analgesic Use and Risk of Hearing Loss in Women
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DOI：
10.1093/aje/kww154
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发表时间：
2017-01-01
影响因子：
5
通讯作者：
Curhan, Gary C.
中科院分区：
文献类型：
--
作者：
Lin, Brian M.;Curhan, Sharon G.;Curhan, Gary C.
阿司匹林，非甾体抗炎药（NSAID）和对乙酰氨基酚是常用的。经常使用止痛剂与听力损失的高风险有关。然而，镇痛药使用时间与听力损失风险之间的关系尚不清楚。我们在护士健康研究中调查了55,850名妇女使用镇痛药的持续时间与自我报告的听力损失之间的关系。Cox比例风险回归用于校正潜在混杂因素。在873,376人年的随访（1990-2012）中，较长的NSAID使用时间（> 6年与< 1年相比，多变量调整相对风险= 1.10,95%置信区间：1.06,1.15;P < 0.001）和对乙酰氨基酚使用时间（> 6年与< 1年相比，多变量调整相对风险= 1.09,95%置信区间：1.04,1.14;P < 0.001）与较高的听力损失风险相关。服用阿司匹林的持续时间与听力损失无关（服用阿司匹林6年与< 1年相比，多变量校正相对风险= 1.01,95%可信区间：0.97,1.05；趋势P = 0.35）。在这组女性中，服用非甾体抗炎药和对乙酰氨基酚的时间越长，听力损失的风险越高，但服用阿司匹林的时间却没有。考虑到止痛药使用的高流行率，这可能是听力损失的一个重要的可改变因素。
Aspirin, nonsteroidal antiinflammatory drugs (NSAID), and acetaminophen are commonly used. Frequent use of analgesics has been associated with a higher risk of hearing loss. However, the association between duration of analgesic use and the risk of hearing loss is unclear. We investigated the relationship between duration of analgesic use and self-reported hearing loss among 55,850 women in the Nurses' Health Study. Cox proportional hazards regression was used to adjust for potential confounders. During 873,376 personyears of follow-up (1990-2012), longer durations of NSAID use (for > 6 years of use compared with < 1 year, multivariable-adjusted relative risk = 1.10, 95% confidence interval: 1.06, 1.15; P for trend < 0.001) and acetaminophen use (for > 6 years of use compared with < 1 year, multivariable-adjusted relative risk = 1.09, 95% confidence interval: 1.04, 1.14; P for trend < 0.001) were associated with higher risks of hearing loss. Duration of aspirin use was not associated with hearing loss (for > 6 years of use compared with < 1 year, multivariableadjusted relative risk = 1.01, 95% confidence interval: 0.97, 1.05; P for trend = 0.35). In this cohort of women, longer durations of NSAID and acetaminophen use were associated with slightly higher risks of hearing loss, but duration of aspirin use was not. Considering the high prevalence of analgesic use, this may be an important modifiable contributor to hearing loss.