INFLUENCE OF THE METHOD OF DRUG ADMINISTRATION ON ANALGESIC RESPONSE
INFLUENCE OF THE METHOD OF DRUG ADMINISTRATION ON ANALGESIC RESPONSE
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DOI：
10.1038/312755a0
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发表时间：
1984-01-01
期刊：
影响因子：
64.8
通讯作者：
GORDON, NC
中科院分区：
文献类型：
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作者：
LEVINE, JD;GORDON, NC
安慰剂诱导镇痛研究中合适的对照组尚未建立。传统的对照是“不治疗”或自然历史组。在一些研究中，自然历史组接受隐藏的载体输注，这是一种生理上不活跃的物质，例如盐水溶液，以消除实验者对结果预期的差异1,2。为了评估“隐藏”和开放输注载体是否可以引起安慰剂反应，我们现在测试了不同的自然历史组，该组从可编程定时器控制的注射泵接受载体输注。这两个对照组的比较提供了证据，表明隐藏的载体输注可以引起安慰剂反应。使用这个新的对照组还可以清楚地区分安慰剂镇痛的纳洛酮拮抗成分和手术应激引起的内啡肽介导的镇痛的纳洛酮拮抗作用。我们的研究强调了安慰剂的力量，并强调即使是最微妙的线索也能引起安慰剂反应。
The appropriate control group in studies of placebo-induced analgesia has not been established. A traditional control has been a ‘no treatment’ or natural-history group. In some studies, the natural-history group receives a hidden infusion of vehicle, a physiologically inactive substance such as saline solution, to eliminate differences in expectation of the outcome on the part of the experimenter1,2. To evaluate whether ‘hidden’ as well as open infusion of vehicle can elicit a placebo response, we have now tested a different natural-history group, one which received an infusion of vehicle from a syringe pump controlled by a programmable timer. A comparison of these two control groups provides evidence that hidden infusion of vehicle can elicit a placebo response. Use of this new control group also permitted a clear distinction between a naloxone-antagonizable component of placebo analgesia and naloxone antagonism of endorphin-mediated analgesia induced by surgical stress. Our study underscores the power of the placebo and emphasizes that even the most subtle cues can elicit a placebo response.