Risk factors for incident mild cognitive impairment - results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe)
Risk factors for incident mild cognitive impairment - results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe)
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DOI：
10.1111/j.1600-0447.2009.01481.x
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发表时间：
2010-04-01
影响因子：
6.7
通讯作者：
Kaduszkiewicz, H.
中科院分区：
文献类型：
--
作者：
Luck, T.;Riedel-Heller, S. G.;Kaduszkiewicz, H.
目的：提供老年全科医生（GP）患者（75岁及以上）中轻度认知障碍（MCI）的年龄和性别特异性发病率，并确定MCI发病的风险因素。方法：数据来源于德国初级保健患者衰老、认知和痴呆纵向研究（AgeCoDe）。发病率根据“风险人年”法计算。使用多变量逻辑回归模型分析风险因素。结果：在3年的随访期间，在纳入发病率计算的2331名患者中，有350名（15.0%）发生了MCI[人年（PY）= 6198.20]。MCI的总体发病率为每1000人年56.5例（95%置信区间 = 50.7 - 62.7）。年龄较大、血管疾病、载脂蛋白E ε4等位基因和主观记忆抱怨被确定为未来发生MCI的重要风险因素。结论：轻度认知障碍在老年全科医生患者中较为常见。主观记忆抱怨可预测MCI的发生。特别是血管风险因素为预防方法提供了机会。
Objectives:To provide age- and gender-specific incidence rates of MCI among elderly general practitioner (GP) patients (75+ years) and to identify risk factors for incident MCI.Method:Data were derived from the longitudinal German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe). Incidence was calculated according to the 'person-years-at-risk' method. Risk factors were analysed using multivariate logistic regression models.Results:During the 3-year follow-up period, 350 (15.0%) of the 2331 patients whose data were included in the calculation of incidence developed MCI [person-years (PY) = 6198.20]. The overall incidence of MCI was 56.5 (95% confidence interval = 50.7-62.7) per 1000 PY. Older age, vascular diseases, the apoE epsilon 4 allele and subjective memory complaints were identified as significant risk factors for future MCI.Conclusion:Mild cognitive impairment is frequent in older GP patients. Subjective memory complaints predict incident MCI. Especially vascular risk factors provide the opportunity of preventive approaches.