Interleukin 18 gene polymorphism is a risk factor for multiple sclerosis
Interleukin 18 gene polymorphism is a risk factor for multiple sclerosis
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DOI：
10.1007/s11033-013-3013-5
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发表时间：
2014-03-01
影响因子：
2.8
通讯作者：
Keni, Fatih Mehmet
中科院分区：
文献类型：
--
作者：
Celik, Sevim Karakas;Oz, Zehra Safi;Keni, Fatih Mehmet
具有免疫抑制特性的促炎细胞因子在多发性硬化症（MS）的发病机制中起重要作用。白细胞介素18 （IL-18）是巨噬细胞在炎症免疫反应早期产生的最重要的先天细胞因子之一。本文采用pcr -限制性片段长度多态性（PCR-RFLP）方法对101例MS患者和164例对照者进行了il - 18基因分型，目的是确定il - 18基因多态性与MS之间是否存在相关性。MS患者-137位il - 18基因CC型的发生率显著高于GG基因型[p = 0.01，优势比（OR） 3.17]。在对IL18基因两个snp的单倍型分析中，MS患者CC单倍型的频率显著高于MS患者（p = 0.002, OR 3.0）。而MS患者组il -607 C/A多态性基因型分布与对照组无显著差异。这些数据提示il - 18基因-137位点多态性可能是土耳其人群多发性硬化的遗传危险因素。
Proinflammatory cytokines with immunosuppressive properties play an important role in the pathogenesis of multiple sclerosis (MS). Interleukin 18 (IL-18) is one of the most important innate cytokines produced from macrophages in the early stages of the inflammatory immune response. The purpose of this study was to determine whether there was any relationship between IL18 gene polymorphisms and MS. IL18 genotyping were performed in 101 MS patients and 164 control subjects by using the PCR-restriction fragment length polymorphism (PCR-RFLP) method. The frequency of MS patients with the CC genotype of the IL18 gene at position -137 was significantly higher than with the GG genotype [p = 0.01, odds ratio (OR) 3.17]. In haplotype analysis of two SNPs in the IL18 gene, frequency of the CC haplotype was significantly higher in MS patients (p = 0.002, OR 3.0). However, the genotype distribution of the IL18 -607 C/A polymorphism in the MS patient group was not significantly different from that of the control group. These data suggest that IL18 gene polymorphisms at position -137 might be a genetic risk factor for MS in the Turkish population.