Different metastatic pattern according to the KRAS mutational status and site-specific discordance of KRAS status in patients with colorectal cancer.
Different metastatic pattern according to the KRAS mutational status and site-specific discordance of KRAS status in patients with colorectal cancer.
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根据KRAS突变状态和大肠癌患者KRAS状态的特定地点不一致的不同转移模式。
DOI：
10.1186/1471-2407-12-347
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发表时间：
2012-08-09
期刊：
影响因子：
3.8
通讯作者：
Lee KW
中科院分区：
文献类型：
--
作者：
Kim MJ;Lee HS;Kim JH;Kim YJ;Kwon JH;Lee JO;Bang SM;Park KU;Kim DW;Kang SB;Kim JS;Lee JS;Lee KW
我们评估了KRAS突变状态与各种临床病理特征之间的关系，包括转移性或复发性结直肠癌（MRCRC）患者的转移模式。还分析了原发肿瘤部位和配对转移器官之间KRAS状态的一致率。通过测序分析确定来自原发性肿瘤和相关转移瘤的福尔马林固定切片的密码子12、13和61中的KRAS突变状态。连续入组了143例具有原发肿瘤和相关转移部位的可用组织（切除或活检）的MRCRC韩国患者。同时考虑原发灶和转移灶时，KRAS突变率为52.4%（75/143）。当分析MRCRC诊断时KRAS状态与初始转移部位之间的关系时，KRAS突变患者的初始转移部位肺转移比无KRAS突变患者更常见（45.3% vs. 22.1%; P = 0.003）。然而，肝脏（37.3% vs. 70.6%; P < 0.001）或远处淋巴结转移（6.7% vs. 19.1%; P = 0.025）在KRAS突变患者中作为初始转移器官的频率低于无KRAS突变患者。原发灶与配对转移灶之间KRAS突变状态的不一致率为12.3%（13/106）。与原发肿瘤部位相比，匹配的肺转移灶的KRAS不一致率[32.4%（12/37）]显著高于其他匹配的转移灶（P = 0.005）。根据MRCRC患者中KRAS突变状态的不同，远处转移最初累及的器官也不同。与原发肿瘤部位相比，肺以外转移部位KRAS突变状态的一致率（87.7%）通常较高;然而，肺转移的KRAS不一致率较高（32.4%）。
We evaluated the association between a KRAS mutational status and various clinicopathologic features including the metastatic pattern in patients with metastatic or recurrent colorectal cancer (MRCRC). The concordance rates of the KRAS status between primary tumor sites and paired metastatic organs were also analyzed. The KRAS mutational status in codons 12, 13, and 61 from formalin-fixed sections of both primary tumors and related metastases was determined by sequencing analysis. One hundred forty-three Korean patients with MRCRC with available tissues (resection or biopsy) from both primary tumors and related metastatic sites were consecutively enrolled. The KRAS mutation rate was 52.4% (75/143) when considering both the primary and metastatic sites. When the relationship between the KRAS status and initial metastatic sites at the time of diagnosis of MRCRC was analyzed, lung metastasis was more frequent as the initial metastatic site in patients with the KRAS mutation than in patients without the KRAS mutation (45.3% vs. 22.1%; P = 0.003). However, liver (37.3% vs. 70.6%; P < 0.001) or distant lymph node metastases (6.7% vs. 19.1%; P = 0.025) were less frequent as the initial metastatic organ in patients with the KRAS mutation than in patients without the KRAS mutation. The discordance rate of KRAS mutational status between primary and paired metastatic sites other than the lung was 12.3% (13/106). Compared with primary tumor sites, the KRAS discordance rate was significantly higher in matched lung metastases [32.4% (12/37)] than in other matched metastatic organs (P = 0.005). Organs initially involved by distant metastasis were different according to the KRAS mutational status in MRCRC patients. The concordance rate (87.7%) of the KRAS mutation status at metastatic sites other than the lung was generally high compared with primary tumor sites; however, lung metastasis had a high rate of KRAS discordance (32.4%).
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影响因子：
--
作者：
Gattenlöhner S;Etschmann B;Kunzmann V;Thalheimer A;Hack M;Kleber G;Einsele H;Germer C;Müller-Hermelink HK
通讯作者：
Müller-Hermelink HK
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影响因子：
4.6
作者：
Jung KW;Park S;Kong HJ;Won YJ;Lee JY;Park EC;Lee JS
通讯作者：
Lee JS
影响因子：
11.5
作者：
Baldus, Stephan E.;Schaefer, Karl-L.;Gabbert, Helmut E.
通讯作者：
Gabbert, Helmut E.
影响因子：
45.3
作者：
Douillard, Jean-Yves;Siena, Salvatore;Gansert, Jennifer
通讯作者：
Gansert, Jennifer
影响因子：
11.5
作者：
Etienne-Grimaldi, Marie-Christine;Formento, Jean-Louis;Milano, Gerard
通讯作者：
Milano, Gerard