Microinfarcts are common and strongly related to dementia in the oldest-old: The 90+ study.
Microinfarcts are common and strongly related to dementia in the oldest-old: The 90+ study.
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DOI：
10.1016/j.jalz.2016.04.006
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Kawas CH
中科院分区：
文献类型：
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作者：
Corrada MM;Sonnen JA;Kim RC;Kawas CH
我们评估了一组年龄最大的老年参与者中微梗死的患病率及其与痴呆的关系。参与者来自90+研究，这是一项针对90岁及以上人群的研究。在一次共识会议上，痴呆症的诊断是在死后进行的。在6个脑区评价了微梗死。死亡时，213名参与者平均年龄为97岁，69%为女性，52%患有痴呆症。51%的参与者有微梗死，17%有3+微梗死。3+微梗死（OR=4.75，p<0.01）和缠结V-VI期（OR = 4.70，p<0.001）痴呆的比值比（OR）相似。只有大脑皮层区域（枕叶除外）的微梗死与痴呆相关。在这个年龄最大的队列中，微梗死是常见的，并且作为缠结独立地和类似地在程度上导致痴呆。由于微梗塞和其他痴呆病理的风险因素可能不同，因此识别这些因素对于制定高龄老人痴呆症的预防策略至关重要。
We estimated the prevalence of microinfarcts and their association with dementia in a cohort of oldest-old participants. Participants were from The 90+ Study, a population-based study of people 90 and older. Dementia diagnoses were assigned post-mortem during a consensus conference. Microinfarcts were evaluated in six brain regions. At death, the 213 participants were on average 97 years old, 69% were women, and 52% had dementia. 51% of participants had microinfarcts and 17% had 3+ microinfarcts. The odds ratio (OR) for dementia was similar for 3+ microinfarcts (OR=4.75, p<0.01) and tangle stage V-VI (OR=4.70, p<0.001). Only microinfarcts in cortical regions (other than occipital) were associated to dementia. In this oldest-old cohort, microinfarcts are common and contribute independently and similarly in magnitude to dementia as tangles. As risk factors for microinfarcts and other dementing pathologies are likely to differ, identifying these factors is crucial to developing prevention strategies for dementia in the oldest-old.