Autonomic response in depersonalization disorder
Autonomic response in depersonalization disorder
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DOI：
10.1001/archpsyc.59.9.833
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发表时间：
2002-09-01
影响因子：
--
通讯作者：
David, AS
中科院分区：
文献类型：
--
作者：
Sierra, M;Senior, C;David, AS
背景情绪加工抑制被认为是导致去个人化和/或去道德化的一些临床特征的一种机制。方法：记录15例慢性去个人化障碍患者(对照组15例，焦虑症患者11例)对非特异性激发物(鼓掌和叹息)和15张不同情绪价态的随机图片(5张不愉快图片，5张愉快图片和5张中性图片)的皮肤电导反应。结果：非个性化障碍患者对不愉快图片的皮肤电导反应显著降低(对照组为0.017个，焦虑症患者为0.103个；P=.01)。此外，去人格化障碍组对这些刺激的反应潜伏期显著延长(3.01秒，而对照组和焦虑组分别为2.5秒和2.1秒；P=0.02)。相反，去人格化和焦虑组对非特定刺激(拍掌和叹息)的潜伏期(1.6秒)明显短于对照组(2.3秒)(P=.03)。结论：去人格化障碍患者对不愉快刺激的自主神经反应减弱。事实上，去人格化障碍患者对令人震惊的噪音反应更早，这表明他们处于高度警觉状态，对不愉快刺激的反应减少是由情绪处理的选择性抑制机制造成的。
Backgrounds Emotional-processing inhibition has been suggested as a mechanism underlying some of the clinical features of depersonalization and/or derealization. In this study, we tested the prediction that autonomic response to emotional stimuli would be reduced in patients with depersonalization disorder.Methods: The skin conductance responses of 15 patients with chronic depersonalization disorder according to DSM-IV, 15 controls, and 11 individuals with anxiety disorders according to DSM-IV, were recorded in response to nonspecific elicitors (an unexpected clap and taking a sigh) and in response to 15 randomized pictures with different emotional valences: 5 unpleasant, 5 pleasant, and 5 neutral.Results: The skin conductance response to unpleasant pictures was significantly reduced in patients with depersonalization disorder (magnitude of 0.017 musiemens in controls and 0.103 musiemens in patients with anxiety disorders; P=.01). Also, the latency of response to these stimuli was significantly prolonged in the group with depersonalization disorder (3.01 seconds compared with 2.5 and 2.1 seconds in the control and anxiety groups, respectively; P=.02). In contrast, latency to nonspecific stimuli (clap and sigh) was significantly shorter in the depersonalization and anxiety groups (1.6 seconds) than in controls (2.3 seconds) (P=.03).Conclusions: In depersonalization disorder, autonomic response to unpleasant stimuli is reduced. The fact that patients with depersonalization disorder respond earlier to a startling noise suggests that they are in a heightened state of alertness and that the reduced response to unpleasant stimuli is caused by a selective inhibitory mechanism on emotional processing.