Intoxicating effects of lorazepam and barbital in rat lines selected for differential sensitivity to ethanol
Intoxicating effects of lorazepam and barbital in rat lines selected for differential sensitivity to ethanol
复制标题
劳拉西泮和巴比妥对乙醇不同敏感性选择的大鼠系的中毒作用
DOI：
10.1007/bf00518174
复制
发表时间：
2004
影响因子：
3.4
通讯作者：
C. Kim
中科院分区：
文献类型：
--
作者：
K. Hellevuo;K. Kiianmaa;A. Juhakoski;C. Kim
The motor impairing effects and plasma concentrations of barbital and lorazepam were studied in the alcohol tolerant (AT) and alcohol non-tolerant (ANT) rat lines developed for low and high sensitivity to motor impairment from ethanol. The mixed (M) line, from which the AT and ANT rats were derived, was also included in the study. Like ethanol, barbital and lorazepam impaired the performance of the ANT rats more than that of the AT rats. The motor performance of the M rats was relatively more impaired after barbital than after lorazepam administration at the same dose used in the AT and ANT rats. At the two latter time points (2.5 and 3.5 h) the sensitive ANT rats had significantly higher serum barbital concentrations than the AT rats. The serum barbital concentrations of the AT and ANT rats did not differ, however, at the two first time points (0.5 and 1.5 h) of the tilting plane tests, although the ANT rats were significantly more intoxicated. The concentrations of lorazepam in plasma do not explain the differential motor impairment either, since the sensitive ANT rats had lower plasma concentrations than the insensitive AT rats. The results, thus, suggest that the selection involved in the development of the AT and ANT lines has not been specific for ethanol. The results also support the idea that ethanol, barbiturates and benzodiazepines have some modes of action in common.
