MECHANISM OF THE INTERACTION MEDIATING KILLING OF SCHISTOSOMA-MANSONI BY HUMAN EOSINOPHILS
MECHANISM OF THE INTERACTION MEDIATING KILLING OF SCHISTOSOMA-MANSONI BY HUMAN EOSINOPHILS
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DOI：
10.4269/ajtmh.1980.29.842
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发表时间：
1980-01-01
影响因子：
3.3
通讯作者：
VADAS, MA
中科院分区：
文献类型：
--
作者：
DAVID, JR;BUTTERWORTH, AE;VADAS, MA
嗜酸性粒细胞在抗链球菌免疫中的作用。曼森总结说。体外研究表明，人嗜酸性粒细胞可以杀死抗体覆盖的童虫。嗜酸性粒细胞介导的杀伤与这些细胞的粘附以及随后的脱粒和嗜酸性粒细胞主要碱性蛋白释放到幼虫上有关。主要的碱性蛋白本身就能杀死幼虫。抗体依赖性嗜酸性粒细胞粘附幼虫进行至少2个不同的步骤。第一个是由Fc受体介导的，并且相对较弱;第二个是温度依赖性步骤，其允许嗜酸性粒细胞与嗜酸性粒细胞的牢固的、不可逆的结合。这种稳定的结合与嗜酸性粒细胞的脱粒有关，这一过程似乎有助于该细胞介导抗体依赖性损伤的优先能力。
Recent work on the role of eosinophils in immunity to S. mansoni is summarized. In vitro studies have shown that human eosinophils can kill antibody-covered schistosomula. The killing mediated by eosinophils is associated with adherence of these cells and subsequent degranulation and release of eosinophil major basic protein onto the larvae. The major basic protein itself can kill the larvae. Antibody-dependent eosinophil adherence to the larvae proceeds in at least 2 distinct steps. The 1st is mediated by Fc receptors and is relatively weak; the 2nd is a temperature-dependent step which allows firm, irreversible binding of eosinophils to schistosomula. This stable binding is associated with degranulation of eosinophils, a process which appears to contribute to the preferential capacity of this cell to mediate antibody-dependent damage to schistosomula.