REGENERATION BY SUPERNUMERARY AXONS WITH SYNAPTIC TERMINALS IN SPINAL MOTONEURONS OF CATS
REGENERATION BY SUPERNUMERARY AXONS WITH SYNAPTIC TERMINALS IN SPINAL MOTONEURONS OF CATS
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DOI：
10.1038/325711a0
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发表时间：
1987-02-19
期刊：
影响因子：
64.8
通讯作者：
KELLERTH, JO
中科院分区：
文献类型：
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作者：
HAVTON, L;KELLERTH, JO
哺乳动物中枢神经系统(CNS)中的轴突如果被切断，通常不会再生，这严重限制了损伤后功能的恢复。用辣根过氧化物酶标记单个细胞，研究了成年猫脊髓α运动神经元外周慢性切断轴突后的反应。手术12周后，大约三分之一的轴突细胞形成了源自细胞体区域的“多余的”轴突。这些多余的轴突在同侧脊髓中有不同的轨迹和终止场，但通常是异常的投射。超微结构检查显示，尽管它们含有α运动轴突中央终末通常看不到的致密核小泡，但它们会产生与神经元轮廓形成形态正常突触接触的突触。我们的结论是，哺乳动物中枢神经系统中的轴突切断神经元可能在没有局部损伤的情况下，通过额外的轴突形成新的突触联系。
Axons in the central nervous system (CNS) of mammals do not normally regrow if they are cut, which severely limits restoration of function after injury. We have studied the reactions of adult cat spinal α-motoneurons after chronic transection of their axons in the periphery by labelling single cells with horseradish peroxidase. Twelve weeks after the operation, about a third of the axotomized cells had developed a 'supernumerary' axon originating from the cell-body region. These supernumerary axons had variable trajectories and termination fields in the ipsilateral spinal cord but generally anomalous projections. Ultrastructural examination shows that they give rise to boutons that form morphologically normal synaptic contacts with neuronal profiles, although they contain dense-cored vesicles not normally seen1,2in central terminals of α-motor axons. We conclude that axotomized neurons in the mammalian CNS may be able to form new synaptic contacts by means of supernumerary axons in the absence of local damage.