Neuromodulation impact on nonlinear firing behavior of a reduced model motoneuron with the active dendrite.
Neuromodulation impact on nonlinear firing behavior of a reduced model motoneuron with the active dendrite.
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DOI：
10.3389/fncom.2014.00110
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发表时间：
2014
影响因子：
3.2
通讯作者：
Heckman CJ
中科院分区：
文献类型：
--
作者：
Kim H;Heckman CJ
来自脑干系统的神经调节输入通过改变树突中持续性内向电流（PIC）的激活特性来调节脊髓运动神经元的正常功能。然而，PIC对点火输出的影响还取决于其在树突树中的位置。为了研究PIC神经调节和PIC位置依赖性之间的相互作用，我们使用了一个两室模型，该模型在生物学上是现实的，因为它保留了索马和树突之间的方向和频率依赖性电耦合，如在基于运动神经元的完整解剖重建的多室模型中所见。我们的两室的方法使我们能够系统地改变索马和树突之间的耦合参数，以准确地再现非线性（滞后）运动神经元放电模式的产生上的树突PIC的位置的影响。我们的研究结果表明，作为一个单一的参数值PIC激活增加或减少了20%，从其默认值，非线性点火输出的耦合参数值的解决方案空间急剧减少了约80%。因此，该模型往往只在大多数树枝状PIC网站的线性模式发射。当PIC激活的所有参数同时仅改变约± 10%时，获得相同的结果。我们的研究结果表明，神经调节的民主化效应：脑干系统的神经调节可能发挥作用，在切换运动神经元与PIC在不同的树突位置到一个类似的模式，通过减少树突位置的PIC上的放电行为的影响。
Neuromodulatory inputs from brainstem systems modulate the normal function of spinal motoneurons by altering the activation properties of persistent inward currents (PICs) in their dendrites. However, the effect of the PIC on firing outputs also depends on its location in the dendritic tree. To investigate the interaction between PIC neuromodulation and PIC location dependence, we used a two-compartment model that was biologically realistic in that it retains directional and frequency-dependent electrical coupling between the soma and the dendrites, as seen in multi-compartment models based on full anatomical reconstructions of motoneurons. Our two-compartment approach allowed us to systematically vary the coupling parameters between the soma and the dendrite to accurately reproduce the effect of location of the dendritic PIC on the generation of nonlinear (hysteretic) motoneuron firing patterns. Our results show that as a single parameter value for PIC activation was either increased or decreased by 20% from its default value, the solution space of the coupling parameter values for nonlinear firing outputs was drastically reduced by approximately 80%. As a result, the model tended to fire only in a linear mode at the majority of dendritic PIC sites. The same results were obtained when all parameters for the PIC activation simultaneously changed only by approximately ±10%. Our results suggest the democratization effect of neuromodulation: the neuromodulation by the brainstem systems may play a role in switching the motoneurons with PICs at different dendritic locations to a similar mode of firing by reducing the effect of the dendritic location of PICs on the firing behavior.
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