Studies on the outcome of lupus nephritis according to long-term treatment employing different modes of immunotherapy.
Studies on the outcome of lupus nephritis according to long-term treatment employing different modes of immunotherapy.
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采用不同免疫治疗模式长期治疗狼疮性肾炎的结果研究。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
S. Hirose
中科院分区：
文献类型：
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作者：
H. Hashimoto;M. Sugawara;H. Tsuda;K. Kabasawa;S. Hirose
研究了不同免疫疗法下狼疮性肾炎长期治疗的结果，以及影响狼疮性肾炎结果的因素。将212例狼疮性肾炎患者根据不同的治疗方式分为5组：（1）泼尼松龙（PSL）初始剂量低于39 mg/天，（2）PSL初始剂量高于40 mg/天，（3）冲击疗法和类固醇，（4）类固醇和免疫抑制剂，（5）血浆置换与其他疗法的联合治疗。狼疮性肾炎的结果分为5个等级。结果，狼疮性肾炎的完全缓解率为9.4%。所有治疗方式的 5 年生存率均有所提高。然而，不可能确定哪种治疗方式可以带来最高的缓解率。在狼疮性肾炎缓解期患者中，观察到肾外受累减少和补体水平降低，同时 IgM 抗 DNA 抗体增加。
The outcome of long-term treatment of lupus nephritis under different immunotherapies, together with the factors affecting the outcome of lupus nephritis, was studied. A total of 212 lupus nephritis patients were classified into 5 groups according to their different modes of treatment: (1) initial dose of prednisolone (PSL) below 39 mg/day, (2) initial dose of PSL above 40 mg/day, (3) pulse therapy and steroids, (4) steroids and immunosuppressants, and (5) combination therapy of plasmapheresis with other therapies. The outcome of lupus nephritis was evaluated into 5 grades. As a result, the complete remission rate of lupus nephritis was 9.4%. The 5-year survival rates increased with all modes of treatment. However, it was impossible to identify which mode of therapy could bring about the highest rate of remission. Decreases in extrarenal involvement and low complement levels were observed together with increases in IgM anti-DNA antibodies among the lupus nephritis patients with remission.