Highly selective and sensitive turn-on fluorescent sensor for detection of Al3+ based on quinoline-base Schiff base.
Highly selective and sensitive turn-on fluorescent sensor for detection of Al3+ based on quinoline-base Schiff base.
复制标题
DOI：
10.1016/j.saa.2018.01.049
复制
发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Yang Wang;Zhong-Ying Ma;Detao Zhang;Jia-li Deng;Xiong Chen;Cheng-Zhi Xie;Xin Qiao;Qingzhong Li;Jing‐Yuan Xu
中科院分区：
文献类型：
--
作者：
Yang Wang;Zhong-Ying Ma;Detao Zhang;Jia-li Deng;Xiong Chen;Cheng-Zhi Xie;Xin Qiao;Qingzhong Li;Jing‐Yuan Xu
一种新型铝离子荧光探针（4-（二乙氨基）-2-羟基亚苯亚甲基）异喹啉-1-碳酰肼（HL1）已被方便地合成和表征。 HL1 通过形成 2:1 配合物，与其他常见阳离子相比，对 Al3+ 的荧光发射表现出高度选择性和显着增强，其识别机制基于激发态分子内质子转移 (ESIPT) 和分子内电荷转移 (ICT)。在 Al3+ 存在的情况下，即使探针浓度为 ppm 级，也可以观察到强烈的荧光发射，在 545 nm 处强度增强 41 倍。 HL1在低浓度下与Al3+表现出良好的线性关系，检测限为8.08×10−8mol/L。合成了水杨醛苯环上具有不同取代基的相似分子以研究构效关系。密度泛函理论（DFT）计算与所提出的机制一致。证实HL1可用于荧光光谱法检测实际样品中的Al3+离子，并可通过生物成像检测细胞中的Al3+离子。
A new aluminum ion fluorescent probe (4-(diethylamino)-2-hydroxybenzylidene)isoquinoline-1-carbohydrazide (HL1) has been conveniently synthesized and characterized. HL1exhibited a highly selective and pronounced enhancement for Al3+in the fluorescence emission over other common cations by forming a 2:1 complex, with a recognition mechanism based on excited-state intramolecular proton transfer (ESIPT) and intramolecular charge transfer (ICT). The strong fluorescent emission can be observed even at ppm level concentration of the probe in the presence of Al3+with 41 fold intensity enhancement at 545 nm. HL1displays good linear relationship with Al3+in the low concentration and the limit of detection is 8.08 × 10−8mol/L. Similar molecules with different substituents on salicylaldehyde phenyl ring were synthesized for studying the structure-activity relationship. Density-functional theory (DFT) calculations are in agreement with the proposed mechanism. It is confirmed that HL1could be used to detect Al3+ions in real sample by fluorescence spectrometry and Al3+ions in cells by bioimaging.