Synthesis and characteristics of (Hydrogenated) ferulic acid derivatives as potential antiviral agents with insecticidal activity.
Synthesis and characteristics of (Hydrogenated) ferulic acid derivatives as potential antiviral agents with insecticidal activity.
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具有杀虫活性的潜在抗病毒剂（氢化）阿魏酸衍生物的合成及特性
DOI：
10.1186/1752-153x-7-33
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发表时间：
2013-02-14
影响因子：
--
通讯作者：
Zhao WG
中科院分区：
文献类型：
--
作者：
Huang GY;Cui C;Wang ZP;Li YQ;Xiong LX;Wang LZ;Yu SJ;Li ZM;Zhao WG
背景植物病毒引起许多严重的植物病害，目前通过同时使用杀病毒剂和杀虫剂来抑制。然而，这些材料的使用增加了环境中污染物的量。为了减少环境污染物，杀病毒剂与杀虫活性是一个有吸引力的选择。ResultsA系列取代阿魏酸酰胺衍生物7和相应的氢化阿魏酸酰胺衍生物13的合成和评价其抗病毒和杀虫活性。大多数合成的化合物表现出良好的抗烟草花叶病毒（TMW）的抗病毒活性水平，其中化合物7a、7 b和7 d特别地在500 μg/mL下提供比对照化合物利巴韦林更高水平的抗TMV的保护和治疗活性。此外，这些化合物显示出良好的杀虫活性，对昆虫的刺吸式口器，可以传播植物病毒之间和作物内conclusions.Conclusions2系列阿魏酸衍生物已有效地合成。生物活性测定表明，标题化合物不仅能抑制植物病毒的侵染，而且能阻止植物病毒通过昆虫媒介的传播。因此，这些发现表明阿魏酸酰胺代表了未来抗病毒研究的新模板。
BackgroundPlant viruses cause many serious plant diseases and are currently suppressed with the simultaneous use of virucides and insecticides. The use of such materials, however, increases the amounts of pollutants in the environment. To reduce environmental contaminants, virucides with insecticidal activity is an attractive option.ResultsA series of substituted ferulic acid amide derivatives 7 and the corresponding hydrogenated ferulic acid amide derivatives 13 were synthesized and evaluated for their antiviral and insecticidal activities. The majority of the synthesized compounds exhibited good levels of antiviral activity against the tobacco mosaic virus (TMW), with compounds 7a, 7b and 7d in particular providing higher levels of protective and curative activities against TMV at 500 μg/mL than the control compound ribavirin. Furthermore, these compounds displayed good insecticidal activities against insects with piercing-sucking mouthparts, which can spread plant viruses between and within crops.ConclusionsTwo series of ferulic acid derivatives have been synthesized efficiently. The bioassay showed title compounds not only inhibit the plant viral infection, but also prevented the spread of plant virus by insect vectors. These findings therefore demonstrate that the ferulic acid amides represent a new template for future antiviral studies.