Comparison of nicotine and carcinogen exposure with water pipe and cigarette smoking.
Comparison of nicotine and carcinogen exposure with water pipe and cigarette smoking.
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DOI：
10.1158/1055-9965.epi-12-1422
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发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Benowitz NL
中科院分区：
文献类型：
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作者：
Jacob P 3rd;Abu Raddaha AH;Dempsey D;Havel C;Peng M;Yu L;Benowitz NL
在世界许多地方使用水烟（水烟）吸食烟草制品很普遍，并且许多人认为相对安全。我们研究了水烟与吸烟的毒物暴露生物标志物。我们进行了一项交叉研究，评估 13 名有使用过这两种产品经验的人每日通过水烟和吸烟接触尼古丁和致癌物的情况。与每天吸 11 支香烟相比，平均吸 3 支水烟，与吸烟相比，使用水烟与尼古丁摄入量显着降低、一氧化碳暴露量增加以及不同的致癌物暴露模式相关，苯和高分子量多环芳烃暴露量更大，但烟草特有的亚硝胺、1,3-丁二烯和丙烯醛暴露量较少。 丙烯腈、环氧丙烷、环氧乙烷和低分子量多环芳烃。不同的致癌物暴露模式可能会导致吸烟和吸水烟之间不同的癌症风险状况。特别值得关注的是与使用水管时接触高浓度苯有关的白血病风险。在美国和世界各地，用水烟斗吸食烟草已经很流行。许多人认为，吸水烟不会使人上瘾，而且比吸香烟危害更小。我们提供有关有毒物质暴露的数据，这将有助于指导有关水管健康风险的监管和公众教育。
Smoking tobacco preparations in a water pipe (hookah) is widespread in many places of the world and is perceived by many as relatively safe. We investigated biomarkers of toxicant exposure with water pipe compared to cigarette smoking. We conducted a cross-over study to assess daily nicotine and carcinogen exposure with water pipe and cigarette smoking in 13 people who were experienced in using both products. While smoking an average of 3 water pipe sessions compared to smoking 11 cigarettes per day, water pipe use was associated with a significantly lower intake of nicotine, greater exposure to carbon monoxide and a different pattern of carcinogen exposure compared to cigarette smoking, with greater exposure to benzene and high molecular weight PAHs, but less exposure to tobacco-specific nitrosamines, 1,3-butadiene and acrolein, acrylonitrile, propylene oxide, ethylene oxide, and low molecular weight PAHs. A different pattern of carcinogen exposure might result in a different cancer risk profile between cigarette and water pipe smoking. Of particular concern is the risk of leukemia related to high levels of benzene exposure with water pipe use. Smoking tobacco in water pipes has gained popularity in the United States and around the world. Many believe that water pipe smoking is not addictive and less harmful than cigarette smoking. We provide data on toxicant exposure that will help guide regulation and public education regarding water pipe health risk.