Expansion of Small-diameter Abdominal Aortic Aneurysms is Not Reflected by the Release of Inflammatory Mediators IL-6, MMP-9 and CRP in Plasma
Expansion of Small-diameter Abdominal Aortic Aneurysms is Not Reflected by the Release of Inflammatory Mediators IL-6, MMP-9 and CRP in Plasma
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DOI：
10.1016/j.ejvs.2008.11.027
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发表时间：
2009-04-01
影响因子：
5.7
通讯作者：
Parsson, H.
中科院分区：
文献类型：
--
作者：
Karlsson, L.;Bergqvist, D.;Parsson, H.
目的：本研究的目的是评估血浆白细胞介素-6（IL-6）、金属蛋白酶-9（MMP-9）和C反应蛋白（CRP）水平与小腹主动脉瘤（AAA）扩张之间的可能相关性。设计图：患者选自前瞻性随机临床试验，并分为两组，其中一组接受活性治疗（阿奇霉素），另一组接受安慰剂。两组间AAA的扩张率无统计学差异，两组被认为是一个队列，在本study.Material和方法：在这项研究中，213例AAA之间的35和49 mm的患者进行了随访，超声检查，每6个月。两次采集血样（间隔6个月）。使用Quantikine分析试剂盒（R&D Systems，Inc.，USA）。结果：IL-6、MMP-9、CRP水平与AAA扩张程度无相关性。他汀类药物与MMP-9水平在6个月内的变化之间也没有任何相关性。他汀类药物的患者比那些没有服用他汀类药物的塔扩张率：0.16与0.25 cm/year.Conclusion：循环IL-6，MMP-9，CRP和小直径AAA的扩张水平之间没有相关性，表明这些标志物在AAA监测中没有临床应用。(C)2008年欧洲血管外科学会。由爱思唯尔有限公司出版。保留所有权利。
Objectives: The aim of this study was to evaluate a possible correlation between plasma levels of interteukin-6 (IL-6), metalloproteinase-9 (MMP-9) and C-reactive protein (CRP) and the expansion of small abdominal aortic aneurysms (AAAs). Design: Patients were selected from a prospective randomised clinical trial and categorised in two groups, in which one group received active treatment (azithromycin) and the other received placebo. No statistical difference in the expansion rate of AAAs between the groups was found and the two groups were considered as one cohort in the present study.Material and methods: In this study, 213 patients with AAAs between 35 and 49 mm were followed-up with ultrasound examination every 6th month. Blood samples were taken on two occasions (6 months apart). IL-6 and MMP-9 were analysed on one occasion using Quantikine (R) analysing kits (R&D Systems, Inc., USA). CRP was analysed using sensitive-CRP method.Results: Levels of IL-6, MMP-9 and CRP did not correlate with AAA expansion. Neither was there any correlation between statin medication and changes in MMP-9 levels over the 6-month period. Patients on statins had a tower expansion rate than those not taking statins: 0.16 versus 0.25 cm per year.Conclusion: No correlation was found between levels of circulating IL-6, MMP-9, CRP and the expansion of small-diameter AAAs, indicating no clinical use of these markers in AAA surveillance. (C) 2008 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.