Multiple Export Mechanisms for mRNAs.
Multiple Export Mechanisms for mRNAs.
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DOI：
10.3390/cells4030452
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发表时间：
2015-08-28
期刊：
影响因子：
6
通讯作者：
Borden KL
中科院分区：
文献类型：
--
作者：
Delaleau M;Borden KL
核mRNA输出在基因表达中起重要作用。我们描述了mRNA输出的机制，包括mRNP组装的重要性，与核孔复合物（NPC）的核篮对接，通过NPC的中央通道转运和胞质释放。我们描述了多种mRNA输出机制，包括NXF1和CRM1介导的途径。mRNA的选择性基团可以优先运输，以响应细胞刺激。可以基于特异性顺式作用RNA元件的存在和特异性衔接蛋白的结合来选择RNA。这一过程的失调在人类疾病中发挥的作用也进行了讨论。
Nuclear mRNA export plays an important role in gene expression. We describe the mechanisms of mRNA export including the importance of mRNP assembly, docking with the nuclear basket of the nuclear pore complex (NPC), transit through the central channel of the NPC and cytoplasmic release. We describe multiple mechanisms of mRNA export including NXF1 and CRM1 mediated pathways. Selective groups of mRNAs can be preferentially transported in order to respond to cellular stimuli. RNAs can be selected based on the presence of specific cis-acting RNA elements and binding of specific adaptor proteins. The role that dysregulation of this process plays in human disease is also discussed.