Lessons from a small, dispensable genome: The mitochondrial genome of yeast
Lessons from a small, dispensable genome: The mitochondrial genome of yeast
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DOI：
10.1016/j.gene.2005.03.024
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发表时间：
2005-07-18
期刊：
影响因子：
3.5
通讯作者：
Bernardi, G
中科院分区：
文献类型：
--
作者：
Bernardi, G
本文综述了作者实验室在世纪（准确地说是1966年至1992年）的四分之一时间里对酵母线粒体基因组进行的研究。我们的研究涉及线粒体基因组的细胞质小突变、复制、转录和重组的结构基础，线粒体基因组是一个非编码序列丰富的基因组。这项工作导致了一些关于真核生物核基因组的一般性结论。最近的一些结果与我们关于ori序列的结论明显矛盾，也将简要讨论。(c)2005 Elsevier B.V.保留所有权利。
This article reviews the investigations on the mitochondrial genomes of yeast carried out in the author's laboratory during a quarter of a century (to be precise between 1966 and 1992). Our studies dealt with the structural basis for the cytoplasmic petite mutation, the replication, the transcription and the recombination of the mitochondrial genome, a genome which is dispensable and which comprises abundant non-coding sequences. This work led to some general conclusions on the nuclear genome of eukaryotes. Some recent results in apparent contradiction with our conclusions on ori sequences will also be briefly discussed. (c) 2005 Elsevier B.V. All rights reserved.