Cytotoxic‐loaded albumin microspheres: A novel approach to regional chemotherapy
Cytotoxic‐loaded albumin microspheres: A novel approach to regional chemotherapy
复制标题
负载细胞毒性的白蛋白微球：区域化疗的新方法
DOI：
10.1002/bjs.1800750214
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发表时间：
1988
影响因子：
9.6
通讯作者：
N. Willmott
中科院分区：
文献类型：
--
作者：
C. Mcardle;H. Lewi;D. Hansell;D. Kerr;J. Mckillop;N. Willmott
以戊二醛为交联剂，制备了阿霉素质量分数为1%的阿霉素载药白蛋白微球(直径15~40μm)。大鼠全身给药后，微球被困在肺毛细血管床内，生物降解超过48h，兔肾动脉内选择性注射99mTc标记白蛋白微球后，97%的微球被困在肾脏内，对侧肾、肺和肝脏的滞留率不到1%。选择性肝动脉注射后也得到了类似的结果。选择性注射细胞毒微球可以提供一种可靠的方法，在不产生高血清水平的情况下将高浓度的细胞毒药物注射到靶器官；这项技术可能在实体肿瘤的治疗中发挥作用。
Adriamycin®‐loaded albumin microspheres (15–40 μm diameter) incorporating 1 per cent by weight of Adriamycin were prepared by cross linking albumin with glutaraldehyde. After systemic administration in rats, the microspheres were trapped in the pulmonary capillary bed, biodegradation occurring over 48 h. After selective intrarenal arterial injection of 99mTc‐labelled albumin microspheres in rabbits, 97 per cent of the injected microspheres were trapped within the kidney; less than 1 per cent were found in the contralateral kidney, lungs and liver. Similar results were obtained after selective intrahepatic arterial injection. The selective injection of cytotoxic‐loaded microspheres may provide a reliable method of administering high concentrations of cytotoxic drug to a target organ without producing high serum levels; this technique may have a role in the management of solid tumours.