Non-invasive assessment of skeletal kinetics using fluorine-18 fluoride positron emission tomography: evaluation of image and population-derived arterial input functions
Non-invasive assessment of skeletal kinetics using fluorine-18 fluoride positron emission tomography: evaluation of image and population-derived arterial input functions
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DOI：
10.1007/s002590050474
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发表时间：
1999-11-01
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影响因子：
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通讯作者：
Fogelman, I
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作者：
Cook, GJR;Lodge, MA;Fogelman, I
为了利用氟-18氟正电子发射断层扫描（PET）测量区域骨骼动力学，有必要了解经动脉血浆输送到骨骼的放射性示踪剂浓度与时间、动脉输入函数（IFa）的关系。不需要动脉采样就可以得到IFa的方法是有吸引力的，因为它们相对技术简单，并且减少了受试者可能的发病率。我们比较了10名正常绝经后妇女的比例总体输入函数（IFp）和校正后的主动脉图像输入函数（IFi）与直接从桡动脉线测量的IFa的使用。上述两种方法仅依赖于少量离散的静脉样本。每位受试者在静脉注射180 MBq f -18氟化物后进行腰椎动态PET采集。将IFp和IFi与IFa在6个参数测定的准确性方面进行比较。这些是：血浆氟化物对骨矿物质的清除率（k -i），血浆对总骨组织的单向清除率（k -1）和个体速率常数k(2), k(3)和k(4)，使用三室模型非线性回归计算，血浆对骨矿物质的清除率使用Patlak方法计算（k -pat）。对于IFp和IFi方法，K-pat和K-i的均方根误差相似且很小(
To measure regional skeletal kinetics using fluorine-18 fluoride positron emission tomography (PET) it is necessary to know the concentration of radioactive tracer being delivered to bone by arterial plasma with relation to time, the arterial input function (IFa). Methods by which IFa can be derived without arterial sampling are attractive because of their relative technical simplicity and the reduction in possible morbidity to the subject. We have compared the use of a scaled population input function (IFp) and a corrected image-derived input function from the aorta (IFi) with an IFa directly measured from a radial artery line in ten normal postmenopausal women. Both of the aforementioned methods rely only on a small number of discrete venous samples. Each subject had a dynamic PET acquisition of the lumbar spine performed after the intravenous injection of 180 MBq F-18-fluoride. Both the IFp and the IFi were compared with the IFa in terms of the accuracy of determination of six parameters. These were: plasma clearance of fluoride to bone mineral (K-i), unidirectional plasma clearance to total bone tissue (K-1) and individual rate constants k(2), k(3) and k(4), calculated using non-linear regression with a three-compartment model, and the plasma clearance to bone mineral calculated using the Patlak method (K-pat). For both the IFp and the IFi method the root mean square errors for K-pat and K-i were similar and small (